| Cat. No. |
Product Name |
Information |
| PC-20222 |
Ulixertinib
ERK inhibitor
|
BVD-523 (Ulixertinib) is a potent, selective, reversible, ATP-competitive ERK1/2 inhibitor with Ki of 0.3/0.04 nM, respectively. |
| PC-38371 |
Rineterkib
ERK1/2 inhibitor
|
Rineterkib (LTT-462) is a small molecule inhibitor of ERK1/2, has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models. |
| PC-72428 |
ASN007
ERK inhibitor
|
ASN007 (ASN-007) is a potent, selective, orally bioavailable ERK1/2 inhibitor with IC50 of 2 nM against both. |
| PC-72401 |
ASTX029
ERK1/2 inhibitor
|
ASTX029 (ASTX-029) is a highly potent, selective dual-mechanism ERK inhibitor with IC50 of <3 nM for ERK1/2, inhibits both ERK catalytic activity and the phosphorylation of ERK by MEK. |
| PC-72142 |
XMD8-85
ERK5 inhibitor
|
XMD8-85 is a selective ERK5 inhibitor with IC50 of 87 nM in enzyme assay. |
| PC-72141 |
JWG-071
ERK5 inhibitor
|
JWG-071 is a selective Erk5 inhibitor (IC50<20 nM) with reduced Brd4/BET inhibitory activity. |
| PC-72106 |
SF-3-030
ERK1/2 inhibitor
|
SF-3-030 is a novel ATP-dependent/catalytic site inhibitor of ERK1/2, inhibits A375 cell viability with IC50 of 4.9 uM. |
| PC-35813 |
CC-90003
ERK1/2 inhibitor
|
CC-90003 (CC90003) is a potent and selective, covalent ERK1/2 inhibitor with IC50 of 10-20 nM, demonstrates excellent selectivity in a 258-kinase biochemical assay panel. |
| PC-35338 |
AZ6197
ERK1/2 inhibitor
|
AZ6197 (AZ-6197) is a potent, selective, reversible inhibitor of ERK1/2 with IC50 of <0.3 nM (ERK2), inhibits pERK/pRSK with IC50 of 12/62 nM in A375 cells, respectively. |
| PC-35332 |
BAY885
ERK5 inhibitor
|
BAY-885 (BAY885) is a highly potent, selective ERK5 (MAPK7) inhibitor with IC50 of 40 nM, shows high selectivity over a panel of 357 kinases (Eurofins panel). |
| PC-63537 |
Astex ERK inhibitor X
ERK1/2 inhibitor
|
Astex ERK inhibitor X (ERK inhibitor 29) is a potent, selective ERK1/2 inhibitor that inhibits ERK catalytic activity with IC50 of 3 nM. |
| PC-63271 |
AZD0364
ERK1/2 inhibitor
|
Tizaterkib (AZD0364) is a potent, selective, ATP competitive, orally active ERK1/2 inhibitor with IC50 of 0.66 nM in ERK2 biochemical assay, binds similarly to ERK1 and ERK2 with Ki of 3.9 and 3.8 nM. |
