| Cat. No. |
Product Name |
Information |
| PC-62933 |
CI-966
GAT-1 inhibitor
|
CI-966 (PD 126141) is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively. |
| PC-62932 |
CI-966 hydrochloride
GAT-1 inhibitor
|
CI-966 hydrochloride is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively. |
| PC-62931 |
NNC-711
GAT-1 inhibitor
|
NNC-711 is a potent and selective inhibitor of GABA uptake by GAT-1 with IC50 of 0.04 uM. |
| PC-62929 |
NNC 05-2090 hydrochloride
GAT2 inhibitor
|
NNC 05-2090 is a potent selective GABA transporter inhibitor of mGAT2 with Ki of 1.4 uM. |
| PC-61113 |
SNAP-5114
GAT3 inhibitor
|
SNAP5114 (SNAP-5114) is a potent, selective GABA transport 3 (GAT3) inhibitor with IC50 of 5, 21, 388 and 140 uM for hGAT-3, rGAT-2, hGAT-1 and BGT-1, respectively. |
| PC-42093 |
SKF-89976A hydrochloride
GAT-1 inhibitor
|
SKF-89976A hydrochloride is a potent, selective and GABA transporter 1 (GAT1) inhibitor with IC50 of 0.13 uM for hGAT1. |
| PC-26894 |
RPC-425
BGT1 inhibitor
|
RPC425 is a selective inhibitor of betaine-GABA transporter 1 (BGT1, mGAT2) with IC50 of 45 uM. |
| PC-26893 |
EF-1502
GAT1/BGT1 inhibitor
|
EF-1502 (EF1502) is a selective inhibitor of GABA transporter GAT-1/BGT-1, noncompetitively inhibits both mGAT1 and the betaine/GABA transporter mGAT2 (BGT-1)) with Ki of 4 uM and 5 uM respectively, is inactive at GAT3 and GAT4. |
| PC-26892 |
ATPCA hydrochloride
BGT-1 inhibitor
|
ATPCA hydrochloride is a potent substrate-inhibitor of the betaine/GABA transporter 1 (BGT1) with IC50 of 2.5 uM (hBGT1), shows >15-fold selective over hGAT2 and hGAT3, no acitivty against hGAT1. |
| PC-26891 |
BPDBA
BGT-1 inhibitor
|
BPDBA is a potent, subtype selective and noncompetitive inhibitor of betaine/GABA transporter 1 (BGT-1) with IC50 of 20 uM (hBGT-1) and 39 uM ( mouse ortholog mGAT2), shows no activity against hGAT-1/mGAT1, hGAT-2/mGAT3, and hGAT-3/mGAT4. |
| PC-25993 |
SR-THAP
GAT3 inhibitor
|
SR-THAP is a selective inhibitor of human GABA transporter GAT3 with IC50 of 4.9 uM, shows no inhibition on GAT1. |
| PC-24080 |
Tiagabine hydrochloride
GAT1 inhibitor
|
Tiagabine hydrochloride is an anticonvulsant agent and selective inhibitor of
GABA transporter 1 (GAT1) with Ki of 0.1 uM, potently and selectively inhibits GABA reuptake with IC50 of 67, 446 and 182 nM for [3H]GABA uptake in synaptosomes, neurons and glia, respectively. |
