| Cat. No. |
Product Name |
Information |
| PC-42243 |
TPCA-1
IKK-2 inhibitor
|
TPCA-1 (IKK-2 Inhibitor IV) is a potent, selective and orally bioavailable IKK-2 inhibitor with IC50 of 63 nM, TNF cell IC50 of 0.4 uM. |
| PC-42632 |
BMS-345541
IKK-2 inhibitor
|
BMS-345541 is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM, less potent for IKK-1 (IC40=4 uM) and no activity against IKK-ε. |
| PC-42631 |
BMS-345541 hydrochloride
IKK2 inhibitor
|
BMS-345541 hydrochloride is a potent and selective IKK-2 inhibitor with IC50 of 0.3 uM. |
| PC-45622 |
AZD3264
IKK2 inhibitor
|
AZD3264 is a selective small molecule inhibitor of IkB-kinase IKK2 for treatment of inflammatory conditions such as asthma, chronic pulmonary obstructive disorder (COPD) and rheumatoid arthritis. |
| PC-23440 |
LIB3S0280
TBK1 inhibitor
|
LIB3S0280 is a potent TANK-binding kinase 1 (TBK1) inhibitor with IC50 of 493.9 nM, inhibits TBK1 downstream signaling. |
| PC-23157 |
MLN120B dihydrochloride
IKKβ inhibitor
|
MLN120B dihydrochloride (ML120B) is a potent, specific and ATP competitive inhibitor of IKKbeta (IKKβ) with IC50 of 0.06 uM, blocks TNF-α-induced NF-κB activation in multiple myeloma cells through inhibition of IκBα phosphorylation and degradation of IκBα. |
| PC-23156 |
MLN120B
IKKβ inhibitor
|
MLN120B (ML120B) is a potent, specific and ATP competitive inhibitor of IKKbeta (IKKβ) with IC50 of 0.06 uM, blocks TNF-α-induced NF-κB activation in multiple myeloma cells through inhibition of IκBα phosphorylation and degradation of IκBα. |
| PC-22935 |
SU1349
IKKα inhibitor
|
SU1349 is a potent, selective inhibitor of IKKα with Ki of 16 nM, >200-fold selective over IKKβ. |
| PC-22934 |
SU1261
IKKα inhibitor
|
SU1261 is a potent, selective inhibitor of IKKα with Ki of 10 nM, >60-fold selective over IKKβ. |
| PC-22919 |
BT503
KLF15 agonist, IKKβ inhibitor
|
BT503 is a potent small molecule agonist of Krüppel-Like Factor 15 (KLF15) with EC50 of 7.1 nM in luciferase reporter assays, directly inhibits NF-κB signaling by targeting IKKβ (IC50=163 nM). |
| PC-21368 |
MHPAP
IKK inhibitor
|
MHPAP is a potent cell-permeable anti-cytokine compound, inhibits inflammatory cytokines in monocyte/macrophage-like cells, directly binds to IκB kinase (IKK). |
| PC-20897 |
Wedelolactone
IKK inhibitor
|
Wedelolactone is a small molecule inhibitor of LPS-induced caspase-11 expression by directly inhibits the IKK Complex, also inhibits 5-lipoxygenase with IC50 of 2.5 uM. |
