| Cat. No. |
Product Name |
Information |
| PC-20647 |
LY290154
LTD4/E4 antagonist
|
LY290154 is a leukotriene LTD4/E4 antagonist. |
| PC-49347 |
REV5901
Leukotriene Receptor inhibitor
|
REV 5901 (REV5901) is a competitive antagonist of peptidoleukotrienes with binding Ki of 0.7 uM (guinea pig lung membranes), also inhibits rat neutrophil 5-LO with IC50 of 0.12 uM. |
| PC-35978 |
Gemilukast
CysLT1/CysLT2 antagonist
|
Gemilukast (ONO-6950, ONO6950) is a potent, orally active, dual CysLT1 and CysLT2 antagonist with IC50 of 1.7 and 25 nM against human CysLT1 and human CysLT2, respectively. |
| PC-43540 |
Nedocromil
Mast cell stabilizer
|
Nedocromil (FPL59002) is a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes, including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2). |
| PC-35285 |
HAMI3379
CysLT2 antagonist
|
HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively. |
| PC-43487 |
Montelukast sodium
LTD4 receptor inhibitor
|
Montelukast sodium (MK0476, MK-0476) is a potent, selective, orally active leukotriene D4 (LTD4) receptor (CysLT1 receptor) antagonist with Ki of 0.18 nM for guinea pig lung LTD4. |
| PC-63302 |
Amelubant
LTB4 receptor antagonist
|
Amelubant (BIIL 284) is a potent, long-acting, orally active leukotriene B4 (LTB4) receptor antagonist with Ki values of 221 nM and 230 nM in vital cells and membranes. |
| PC-63301 |
BIIL260
LTB4 receptor antagonist
|
BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM. |
| PC-61097 |
ONO-2050297
CysLT1/CysLT2 antagonist
|
ONO-2050297 (ONO 2050297) is potent, selective, dual CysLT1 and CysLT2 antagonist with IC50 of 17 and 0.87 nM, respectively. |
| PC-60862 |
Quininib
CysLT1/CysLT2 antagonist
|
Quininib is a potent inhibitor of developmental angiogenesis in the zebrafish eye, and a cysteinyl leukotriene 1 and 2 receptor (CysLT1 and 2) antaognist with IC50 of 1.2 and 52 uM, respectively. |
| PC-45294 |
Zafirlukast
CysLT1 antagonist
|
Zafirlukast (ICI-204219) is a potent, selective, orally active cysteinyl leukotriene 1 (CysLT1) receptor antagonist with IC50 of 14 nM in cell-based calcium mobilization assays. |
| PC-45775 |
MK-571 sodium salt
LTD4 inhibitor
|
MK-571 sodium is a potent and specific LTD4 receptor antagonist with Ki of 0.22 nM. |
