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Cat. No. Product Name CAS No. Information
PC-62804

SEMBL

1443448-82-5 SEMBL is a potent NF-κB inhibitor that inhibits DNA binding of NF-κB component p65.
PC-60551

NDMC101

1308631-40-4 NDMC101 is a small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.
PC-60550

ABD328

1055896-19-9 ABD328 (ABD-328) is an orally active, small molecule inhibitor of RANKL and TNF signalling that inhibits inflammation in vivo.
PC-49360

IT848

2102435-79-8 IT848 (IT-848) is a potent and specific small molecule NF-κB inhibitor, decreases the affinity of NF-κB all five subunits (Rel A, Rel B, c-Rel, p50 and p52) to their DNA binding sites and disrupts downstream biological events.
PC-49334

sRANKL inhibitor S3-15

2412947-15-8 sRANKL inhibitor S3-15 is a highly potent, orally active inhibitor of soluble RANKL, selectively interrupt soluble RANKL-RANK interaction and without interfering with the membrane RANKL-RANK interaction, shows potent osteoclast inhibition effect with IC50 of 0.19 uM in vitro.
PC-49234

Y1693

Y1693 is a potent, orally active small-molecule RANKL inhibitor, effectively prevents RANKL-induced osteoclastogenesis (89% inhibition at 1 uM) and bone resorption.
PC-47045

CRL1101

328010-30-6 CRL1101 is a small-molecule inhibitor of RelA, binds specifically to RelA (KD=2.3 uM, MST assays) and blockes RelA nuclear translocation in breast cancer cells.

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