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Cat. No. Product Name Information
PC-43026

BMS-983970

Notch inhibitor

BMS-983970 (BMS983970) is a potent, orally active, pan-Notch inhibitor, demonstrates robust anti-tumor activity at tolerated doses in multiple tumor xenograft models..
PC-60556

EDD3

Notch inhibitor

A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes.
PC-60478

BMS-906024

Notch inhibitor

Osugacestat (AL 101, BMS-906024) is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
PC-60004

6-alkynyl Fucose

Notch inhibitor

6-alkynyl Fucose is a fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1.
PC-42154

IMR-1

Notch inhibitor

A small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM).
PC-42155

IMR-1A

Notch inhibitor

IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM).
PC-22605

FLI-06

Notch inhibitor

FLI-06 is a pan-NOTCH receptor inhibitor, blocks Notch trafficking and processing, inhibits endogenous Notch signaling.
PC-63246

Cowanin

Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM.

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