| Cat. No. |
Product Name |
Information |
| PC-43026 |
BMS-983970
Notch inhibitor
|
BMS-983970 (BMS983970) is a potent, orally active, pan-Notch inhibitor, demonstrates robust anti-tumor activity at tolerated doses in multiple tumor xenograft models.. |
| PC-60556 |
EDD3
Notch inhibitor
|
A novel Notch inhibitor that reduces protein expression of NOTCH1, NICD and HES1 in HEK293 cells and downregulates Notch target genes. |
| PC-60478 |
BMS-906024
Notch inhibitor
|
Osugacestat (AL 101, BMS-906024) is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively. |
| PC-60004 |
6-alkynyl Fucose
Notch inhibitor
|
6-alkynyl Fucose is a fucose analog that inhibits Dll-induced Notch signaling by reducing Notch ligand Dll1-Notch1 binding, but not Jag1. |
| PC-42154 |
IMR-1
Notch inhibitor
|
A small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=26 uM). |
| PC-42155 |
IMR-1A
Notch inhibitor
|
IMR-1A is a small molecule inhibitor of the Notch transcriptional activation complex that prevents the recruitment of Maml1 to the Notch Ternary Complex (NTC) on chromatin (IC50=0.5 uM). |
| PC-22605 |
FLI-06
Notch inhibitor
|
FLI-06 is a pan-NOTCH receptor inhibitor, blocks Notch trafficking and processing, inhibits endogenous Notch signaling. |
| PC-63246 |
Cowanin
|
Cowanin is a novel natural product from Garcinia speciosa that inhibits the Notch signaling pathway with IC50 of 2.4 uM. |
