| Cat. No. |
Product Name |
Information |
| PC-49096 |
ARN1468
SERPINA3 inhibitor
|
ARN1468 is an anti-prion, cellular active small molecule targeting SERPINA3 (ITC KD=26 uM), decreases prion accumulation and reduces PrPSc in the ScGT1 RML cell line with EC50 of 8.64 uM. |
| PC-62187 |
DAPH-12
Prion inhibitor
|
DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM). |
| PC-62186 |
DAPH-1
Prion inhibitor, EGFR inhibitor
|
DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture. |
| PC-70278 |
Anle-138b
Prion inhibitor, α-Synuclein inhibitor
|
Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn). |
| PC-60646 |
IND-114338
Prion inhibitor
|
IND-114338 is a novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc. |
| PC-60645 |
IND125
Prion inhibitor
|
IND125 is a potent, brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum. |
