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Cat. No. Product Name Information
PC-49096

ARN1468

SERPINA3 inhibitor

ARN1468 is an anti-prion, cellular active small molecule targeting SERPINA3 (ITC KD=26 uM), decreases prion accumulation and reduces PrPSc in the ScGT1 RML cell line with EC50 of 8.64 uM.
PC-62187

DAPH-12

DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
PC-70278

Anle-138b

Emrusolmin (Anle-138b) is a novel oligomer modulator that blocks the formation of pathological aggregates of prion protein (PrP(Sc)) and of α-synuclein (α-syn).
PC-62186

DAPH-1

DAPH-1 (CGP 52411) is a small molecule that directly inhibits prion protein Sup35 prionogenesis with IC50 of 0.58 uM, inhibits and reverses the formation of Aβ42 fibers and reduces their toxicity to neurons in culture.
PC-60646

IND-114338

A novel antiprion compound with EC50 of 68 nM, significantly increases monoglycosylated/diglycosylated PrPSc..
PC-60645

IND125

A novel brain penetrant antiprion compound with EC50 of 57 nM, prevents both PrP(Sc) accumulation and astrocytic gliosis in the cerebrum.

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