| Cat. No. |
Product Name |
Information |
| PC-72528 |
Nigratine
RIPK1 inhibitor
|
Nigratine (6E11) is a highly specific, non-ATP competitive inhibitor of RIPK1 kinase (IC50=1.6 uM), inhibits necroptosis and ferroptosis. |
| PC-72473 |
ZB-R-55
RIPK1 inhibitor
|
ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772. |
| PC-36135 |
GSK2593074A
RIPK1/RIPK3 inhibitor
|
GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively. |
| PC-36133 |
cRIPGBM chloride
|
cRIPGBM (RIPGBM derivative cRIPGBM, RIPGBM-18) is a metabolite of RIPGBM induces apoptosis in GBM CSCs (EC50=68 nM in GBM 1 cells) by interacting with RIPK2 (Kd=2.3 uM). |
| PC-36132 |
RIPGBM
RIPK2 inhibitor
|
RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells). |
| PC-36066 |
RIPK2 inhibitor OD36
RIPK2 inhibitor
|
RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2. |
| PC-35793 |
GSK547
RIPK1 inhibitor
|
GSK547 (RIP1i, GSK'547, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo. |
| PC-35704 |
HS-1371
RIPK3 inhibitor
|
HS-1371 (HS1371) is a novel potent, ATP-competitive receptor-interacting protein kinase-3 (RIP3 or RIPK3 kinase) inhibitor with IC50 of 20.8 nM. |
| PC-35429 |
CSLP43
RIPK2 inhibitor
|
CSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
| PC-35428 |
CSLP37
RIPK2 inhibitor
|
CSLP37 (RIPK2 inhibitor CSLP37) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 16.3 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling. |
| PC-63388 |
GSK-2982772
RIPK1 inhibitor
|
GSK-2982772 is a potent, selective, ATP competitive RIP1 kinase (RIPK1) inhibitor with IC50 of 16 nM. |
| PC-63258 |
RIPK2 inhibitor 1
|
RIPK2 inhibitor 1 is a novel potent, selective RIPK2 inhibitor with IC50 of 5-10 nM. |
