| Cat. No. |
Product Name |
Information |
| PC-73179 |
GSK2983559-AM
RIPK2 inhibitor
|
GSK2983559-AM is the acitve form of GSK2983559, a potent, selective RIPK2 with IC50 of 5 nM. |
| PC-73017 |
PK68
RIPK1 inhibitor
|
PK68 (RIPK1 inhibitor PK68) is a potent necroptosis inhibitor seletively targeting RIPK1 kinase activity, potently inhibits TNF-induced necroptosis (EC50, 23 and 13 nM in human and mouse cells, respectively). |
| PC-73007 |
Necrostatin-34
RIPK1 inhibitor
|
Necrostatin-34 (Nec-34) is a novel small molecule inhibitor of RIPK1 kinase, inhibits TNFα-induced necroptosis in FADD-deficient Jurkat cells with IC50 of 0.67 uM. |
| PC-72999 |
GSK3145095
RIPK1 inhibitor
|
GSK3145095 (GSK 3145095) is a potent, selective RIP1 Kinase (RIPK1) inhibitor with IC50 of 6.3 nM. |
| PC-72533 |
Eclitasertib
RIPK1 inhibitor
|
Eclitasertib (DNL-758, SAR-443122) is a potent, orally bioavailable, small-molecule RIPK1 inhibitor with IC50 of <1 uM. |
| PC-72529 |
GW440139B
RIPK3 inhibitor
|
GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM. |
| PC-72528 |
Nigratine
RIPK1 inhibitor
|
Nigratine (6E11) is a highly specific, non-ATP competitive inhibitor of RIPK1 kinase (IC50=1.6 uM), inhibits necroptosis and ferroptosis. |
| PC-72473 |
ZB-R-55
RIPK1 inhibitor
|
ZB-R-55 is a potent and selective RIPK1 inhibitor with IC50 of 5.7 nM, 10-fold more potent than GSK2982772. |
| PC-72302 |
SN-6109
RIPK1 inhibitor
|
SN-6109 (SN6109) is a small molecule inhibitor RIPK-1 with IC50 of 0.45 uM in radiometric kinase assays. |
| PC-36135 |
GSK2593074A
RIPK1/RIPK3 inhibitor
|
GSK2593074A (GSK'074, GSK-2593074A) is novel potent, selective RIP1/RIP3 kinase dual inhibitor, directly binds to RIP1 and RIP3 with Kd of 130 and 12 nM, respectively. |
| PC-36133 |
cRIPGBM chloride
|
cRIPGBM (RIPGBM derivative cRIPGBM, RIPGBM-18) is a metabolite of RIPGBM induces apoptosis in GBM CSCs (EC50=68 nM in GBM 1 cells) by interacting with RIPK2 (Kd=2.3 uM). |
| PC-36132 |
RIPGBM
RIPK2 inhibitor
|
RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells). |
