| Cat. No. |
Product Name |
Information |
| PC-21572 |
AC-003
RIPK1 inhibitor
|
AC-003 is a novel oral small-molecule inhibitor of receptor interacting protein kinase 1(RIPK1) and has the potential for treating idiopathic pulmonary fibrosis. |
| PC-21082 |
Zharp2-1
RIPK2 inhibitor
|
Zharp2-1 is a novel potent, selective RIPK2 inhibitor with IC50 of 38.5 nM in ADP-Glo kinase assay, effectively blocks RIPK2 kinase function and NOD-mediated NF-κB/MAPK activation. |
| PC-20562 |
aYM155
YM155 prodrug
|
aYM155 is a brain-penetrating prodrug form of YM155 (Cat. PC-42439, potent survivin inhibitor), displays potent cell killing activity against a broad panel of patient-derived GBM cancer stem-like cells (IC50=0.7-10 nM). |
| PC-20063 |
Oditrasertib
RIPK1 inhibitor
|
Oditrasertib is a potent, selective RIPK1 inhibitor. |
| PC-20036 |
Flizasertib
RIPK1 inhibitor
|
Flizasertib is a potent, selective RIP1 kinase (RIPK1) inhibitor with potential for treating prophylaxis. |
| PC-49449 |
Zharp1-211
RIPK1 inhibitor
|
Zharp1-211 is a potent, selective, type II inhibitor of RIPK1 kinase with IC50 of 53 nM and binding Kd of 8.7 nM. |
| PC-38781 |
Dusquetide
p62 modulator
|
Dusquetide (SGX-942, SGX94) is a 5-amino acid peptide, cell membrane penetrant innate defense regulator (IDR) that modulates the innate immune response to both PAMPs and DAMPs, targets the ZZ domain of p62 and modulates the p62-RIP1 complex. |
| PC-38621 |
ZJU-37
RIPK1 inhibitor
|
ZJU-37 is a novel small molecule, BBB penetrant RIPK1 kinase inhibitor (IC50=366.4 nM) with higher potency than Nec-1s, prevents TNFα-induced necroptosis of Jurkat FADD−/− cells with IC50 of 185.2 nM. |
| PC-73178 |
GSK2983559
RIPK2 inhibitor
|
GSK2983559 is a potent, selective and oral active receptor interacting protein 2 kinase (RIPK2) inhibitor with IC50 of 5-10 nM. |
| PC-72529 |
GW440139B
RIPK3 inhibitor
|
GW440139B is a potent RIPK3 inhibitor, suppresses necroptosis driven by dimerizable RIPK3 with IC50 of 73.6 nM. |
| PC-72302 |
SN-6109
RIPK1 inhibitor
|
SN-6109 (SN6109) is a small molecule inhibitor RIPK-1 with IC50 of 0.45 uM in radiometric kinase assays. |
| PC-62633 |
RIP1-IN-22
|
RIP1-IN-22 is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor with pKi of 9.04. |
