| Cat. No. |
Product Name |
Information |
| PC-42439 |
YM-155
Survivin inhibitor, RIPK2 inhibitor
|
Sepantronium bromide (YM-155) is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM, targets RIPK2 kinase activity. |
| PC-45707 |
RIPK2 inhibitor 2
RIPK2 inhibitor
|
RIPK2 inhibitor 2 (RIPK2-IN-2) is a potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor. |
| PC-42102 |
GSK-583
RIPK2 inhibitor
|
GSK-583 is a potent, selective and orally bioavailable RIPK2 kinase inhibitor with IC50 of 5 nM and 2 nM for human and rat RIP2, respectively. |
| PC-45564 |
WEHI-345
RIPK2 inhibitor
|
WEHI-345 is a potent and selective RIPK2 inhibitor with IC50/Kd of 130/46 nM. |
| PC-42301 |
RIPA-56
RIPK1 inhibitor
|
RIPA-56 is a highly potent, selective, stable Receptor-interacting protein 1 (RIPK1) inhibitor with IC50 of 13 nM. |
| PC-42065 |
GSK-481
RIPK1 inhibitor
|
GSK-481 (GSK481) is a highly potent, monokinase selective and ATP-competitive inhibitor of RIP1 kinase (RIPK1) with biochemical IC50 of 10 nM. |
| PC-23024 |
Citronellol
RIPK1 agonist
|
Citronellol is an orally active inducer of apoptosis and RIPK1 agonist. |
| PC-22669 |
Nec-1s
Necroptosis inhibitor, RIPK1 inhibitor
|
Nec-1s (7-Cl-O-Nec-1) is an optimized derivative of Nec-1 and potent, specific necroptosis inhibitor with EC50 of 210 nM in Jurkat cells, exhibits the protection in an ischemic brain injury model, selectively inhibits RIPK1 and lacks activity against IDO. |
| PC-22668 |
Necrostatin-5
Necroptosis inhibitor, RIPK1 inhibitor
|
Necrostatin-5 (Nec-5) is a potent, specific necroptosis inhibitor with EC50 of 240 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1). |
| PC-22667 |
Necrostatin-1
Necroptosis inhibitor, RIPK1 inhibitor
|
Necrostatin-1 (Nec-1) is a potent, specific and BBB-permeable necroptosis inhibitor with EC50 of 490 nM in Jurkat cells, selectively and allosterically inhibits RIP1 kinase (RIPK-1) with EC50 of 182 nM. |
| PC-21707 |
RIPK1 inhibitor 62
RIPK1 inhibitor
|
RIPK1 inhibitor 62 is a potent, selective, orally bioavailable type-II kinase inhibitor of RIPK1 with IC50 of 3.5 nM (hRIPK1), 200-fold less potent against hRIPK3. |
| PC-21572 |
AC-003
RIPK1 inhibitor
|
AC-003 is a novel oral small-molecule inhibitor of receptor interacting protein kinase 1(RIPK1) and has the potential for treating idiopathic pulmonary fibrosis. |
