| Cat. No. |
Product Name |
Information |
| PC-27154 |
Haloperidol
Sigma-1 receptor antagonist
|
Haloperidol is an antipsychotic agent and a potent dopamine D2 receptor antagonist, also is a high affinity sigma-1 receptor (σ1R) antagonist with Ki of 6 nM. |
| PC-27153 |
Dicloperidine
Sigma-1 receptor antagonist
|
Dicloperidine is a potent, selective sigma-1 receptor (σ1R) antagonist with Ki of 2.6 nM. |
| PC-26651 |
RC-106
Sigma receptor modulator
|
RC-106 is a high affinity, brain-penetrant, pan-sigma receptor modulator with Ki of 12.0 nM and 22.0 nM for S1R and S2R respectively. |
| PC-25927 |
SKF83959 hydrobromide
Sigma-1 receptor PAM
|
SKF83959 hydrobromide is a potent and selective dopamine D1-like receptor partial agonist with binding Ki of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively, also is a potent allosteric modulator of Sigma 1 receptor (S1R), shows anti-seizure activities. |
| PC-25926 |
SKF83959
Sigma-1 receptor PAM
|
SKF83959 is a potent and selective dopamine D1-like receptor partial agonist with binding Ki of 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively, also is a potent allosteric modulator of Sigma 1 receptor (S1R), shows anti-seizure activities. |
| PC-24306 |
CM699
DAT/σ1R antagonist
|
CM699 isa dual-action compound with σ1R antagonist effects and affinity for the DAT with Ki of 311 and 14.1 nM at DAT and σ1Rs, respectively, inhibits DA uptake ex vivo. |
| PC-24212 |
Cutamesine dihydrochloride
Sigma 1 receptor agonist
|
Cutamesine dihydrochloride (SA4503, AGY94806) is a potent, selective sigma 1 receptor (σ1R) agonist, shows igh affinity for sigma 1 receptor with IC50 of 17.4 nM, 100-fold over sigma 2 receptor. |
| PC-24026 |
Fabomotizole hydrochloride
Sigma 1 receptor agonist
|
Fabomotizole hydrochloride (Afobazole, CM346) is a compound with anxiolytic and neuroprotective activities, is an agonist of sigma1-receptor (S1R, Ki=5.9 uM). |
| PC-24025 |
Afobazole
Sigma 1 receptor agonist
|
Afobazole (Fabomotizole, CM346) is a compound with anxiolytic and neuroprotective activities, is an agonist of sigma1-receptor (S1R, Ki=5.9 uM). |
| PC-23425 |
Amylovis-201
Sigma-1 agonist
|
Amylovis-201 is dual-target ligand acting as an anti-amyloidogenic compound and a potent agonist of the σ1 chaperone protein, interferes with Amyloid-β aggregation. |
| PC-22349 |
WLB-87848
Sigma 1 receptor agonist
|
WLB-87848 is a highly potent, selective, orally bioavailable sigma-1 receptor (σ1R) agonist with Ki of 9 nM, with ni significant affinity for σ2R. |
| PC-21111 |
AZ-66
Sigma receptor antagonist
|
AZ-66 is a highly potent S1R/S2R antagonist with Ki of 0.31/1.76 nM, respectively. |
