| Cat. No. |
Product Name |
Information |
| PC-22082 |
PRT062607 hydrochloride
Syk inhibitor, PINK1 inhibitor
|
PRT062607 (P505-15) hydrochloride is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons. |
| PC-22081 |
PRT062607
Syk inhibitor, PINK1 inhibitor
|
PRT062607 (P505-15) is a potent, highly specific, orally bioavailable inhibitor of Syk kinase with IC50 of 1 nM, also potently inhibits both insect and human PINK with an IC50 in the 0.5-3 µM range in HeLa cells and dopaminergic neurons. |
| PC-21064 |
RDN2150
ZAP-70 inhibitor
|
RDN2150 is a potent, selective and covalent ZAP-70 inhibitor with IC50 of 14.6 nM, shows no significant activity against Syk, covalently binds to the C346 residue of ZAP-70. |
| PC-20791 |
3-MB-PP1
ZAP-70 inhibitor
|
3-MB-PP1 is specific inhibitor of analogue-sensitive ZAP70 (ZAP-70(AS)), does not affect Lck or Tec kinase activity, specifically targets ZAP-70AS-dependent events. |
| PC-20054 |
MRL-SYKi
Syk inhibitor
|
MRL-SYKi is a potent, selective inhibitor of Syk (Spleen tyrosine kinase) with IC50 of <100 nM, also potently inhibits ZAP70 (24 nM in vitro). |
| PC-49627 |
MTX-216
Syk inhibitor
|
MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM. |
| PC-49383 |
WC36
Syk-cSH2 inhibitor
|
WC36 is a potent, specific inhibitor of Syk-cSH2 with IC50 of 40 nM, inhibits Syk-cSH2-PIP3 binding, specifically and potently suppresses oncogenic activities of Syk in AML cells. |
| PC-73445 |
Sovleplenib
Syk inhibitor
|
Sovleplenib (HMPL-523) is a highly potent, selective, orally available SYK inhibitor with IC50 of 25 nM, demonstrates anti-tumor activity in B cell lymphomas. |
| PC-73180 |
Entospletinib
Syk inhibitor
|
Entospletinib (GS-9973) is a potent, selective and orally bioavailable Syk kinase inhibitor with IC50 of 7.7 nM. |
| PC-72472 |
RDN009
ZAP-70 inhibitor
|
RDN009 (RDN-009) is a potent, selective, and covalent ZAP-70 kinase inhibitor with IC50 of 55 nM. |
| PC-38196 |
SRX3207
Syk/PI3K inhibitor
|
SRX3207 (SRX-3207) is a potent, orally active dual Syk/PI3K inhibitor with IC50 of 39.9/244/388 nM for Syk/PI3Kα/PI3Kδ, respectively. |
| PC-38018 |
ZAP180013
Zap70 inhibitor
|
ZAP 180013 is a small molecule inhibitor of zeta-chain-associated protein kinase 70 (Zap70) with IC50 of 1.8 uM (fluorescence polarization assay). |
