| Cat. No. |
Product Name |
Information |
| PC-35287 |
C25-140
TRAF6 inhibitor
|
C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity. |
| PC-35105 |
GSK145A
SUMOylation inhibitor
|
GSK145A is a small molecule inhibitor of SUMO-conjugating enzyme E2 with IC50 of 12.5 uM, GSK145A is competitive with the sumoylation of the TRPS1 peptide substrates.. |
| PC-63291 |
UBE2M-DCN1 inhibitor 52
DCN1 inhibitor
|
UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM. |
| PC-63182 |
DI-404
DCN1-UBC12 inhibitor
|
DI-404 is a highly potent, peptidomimetic inhibitor of DCN1-UBC12 protein-protein interaction that bind to DCN1 protein with Kd of 6.9 nM, selectively inhibits the neddylation of cullin 3 over other cullin members. |
| PC-61932 |
NAcM-COV
DCN1 inhibitor
|
NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays. |
| PC-61931 |
NAcM-OPT
DCN1 inhibitor
|
NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM in TR-FRET assays. |
| PC-60017 |
DI-591
DCN1-UBC12 inhibitor
|
DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2. |
| PC-45500 |
TZ9
Rad6 inhibitor
|
RAD6 SMI#9 (TZ9, RAD6 inhibitor 9) is a specific small molecule inhibitor of ubiquitin-conjugating enzyme (E2) Rad6, inhibits Rad6B-ubiquitin thioester formation and subsequent ubiquitin transfer to histone H2A. |
| PC-23077 |
CC0651
Cdc34 inhibitor
|
CC0651 is a specific, allosteric inhibitor of ubiquitin-conjugating enzyme (E2) Cdc34 with IC50 of 1.72 uM for inhibition of ubiquitination of p27Kip1 by hCdc34. |
| PC-22046 |
M435-1279
UBE2T inhibitor
|
M435-1279 is a small molecule inhibitor of UBE2T inhibitor with binding KD of 50.5 uM in MST assay, inhibits the Wnt/β-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradation of RACK1. |
| PC-21311 |
HA-9104
UBE2F inhibitor
|
HA-9104 is a specific small molecule inhibitor of E2 conjugating enzyme UBE2F with IC50 of 33.29 uM for inhibition of cullin-5 neddylation, abrogates UBE2F-NEDD8 thioester formation and inhibits cullin-5 neddylation. |
| PC-20652 |
UM130646
UBCH10 inhibitor
|
UM130646 (UM 130646) is a specific small molecule E2 enzyme UBCH10 inhibitor with IC50 of 20.3 uM in TR-FRET UBCH10 autoubiquitination assays, inhibits UBCH10 E2 activity and antagonizes APC/C-mediated substrate degradation. |
