Cat. No. |
Product Name |
Information |
PC-21370 |
ETC-6152
UBE2T inhibitor
|
ETC-6152 is a potent, specific and covalent E2 ubiquitin ligase UBE2T inhibitor with IC50 of 0.22 uM, targets Cys86 of UBE2T and shows selectivity on UBE2T over UBE2K. |
PC-73071 |
UBE2T/FANCL inhibitor UC2
UBE2T/FANCL inhibitor UC2
|
UBE2T/FANCL inhibitor UC2 (UC2) is a specific small-molecule inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation, inhibits the ubiquitylation of GST-FANCL RINGwith IC50 of 14.8 uM in HTRF ubiquitylation assay. |
PC-72869 |
UC-764865
UBE2N inhibitor
|
UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site. |
PC-72868 |
UC-764864
UBE2N inhibitor
|
UC-764864 (UC764864) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site. |
PC-72230 |
DI-1548
DCN1 inhibitor
|
DI-1548 (DI 1548) is a potent, selective and covalent DCN1 inhibitor with IC50 of 4.6 nM and Ki of <1 nM, does not bind to DCN3. |
PC-38264 |
ML307
Ubc13 inhibitor
|
ML307 is a potent, sub-micromolar (IC50=781 nM), first-in-class, small molecule inhibitor of Ubc13 enzyme activity, >128-fold selective against Caspase-3 and Bfl-1. |
PC-36111 |
WS-383
DCN1 inhibitor
|
WS-383 (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM. |
PC-36110 |
WS-383 hydrochloride
DCN1 inhibitor
|
WS-383 hydrochloride (WS383) is a highly potent, selective, and cellular active inhibitor of DCN1-UBC12 interaction with IC50 of 11 nM. |
PC-35686 |
NSC697923
Ubc13 inhibitor
|
NSC697923 (NSC 697923) is a small molecule that specifically inhibits the activity of the ubiquitin-conjugating (E2) enzyme Ubc13 (UBE2N)-Uev1A. |
PC-35287 |
C25-140
TRAF6 inhibitor
|
C25-140 is a specific, first-in-class small molecule inhibitor of the TRAF6-Ubc13 interaction, binds TRAF6, inhibits TRAF6-Ubc13 interaction and TRAF6 activity. |
PC-35105 |
GSK145A
SUMOylation inhibitor
|
GSK145A is a small molecule inhibitor of SUMO-conjugating enzyme E2 with IC50 of 12.5 uM, GSK145A is competitive with the sumoylation of the TRPS1 peptide substrates.. |
PC-63291 |
UBE2M-DCN1 inhibitor 52
DCN1 inhibitor
|
UBE2M-DCN1 inhibitor 52 is a highly potent inhibitor of DCN1-UBE2M protein-protein interaction with IC50 of 60 nM, inhibits cullin neddylation in pulse-chase NEDD8 transfer assay with EC50 of 80 nM. |