| Cat. No. |
Product Name |
Information |
| PC-28753 |
(S)-8B1i-4
CYP8B1 inhibitor
|
(S)-8B1i-4 is the active enantiomer of 8B1i-4, and potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 46 nM. |
| PC-28752 |
8B1i-4
CYP8B1 inhibitor
|
8B1i-4 (CYP8B1 inhibitor-4) is a potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 71.1 nM and cell-based IC50 of 81.1 nM. |
| PC-28751 |
8B1i-1
CYP8B1 inhibitor
|
8B1i-1 (CMP-194644, CYP8B1 inhibitor-1) is a potent, specific small molecule CYP8B1 (cytochrome P450, family 8, subfamily B, polypeptide 1) inhibitor with biochemical IC50 of 238 nM and cell-based IC50 of 373 nM. |
| PC-28058 |
Metyrapone
11β-hydroxylase inhibitor
|
Metyrapone (Su-4885, NSC-25265) is a potent and orally active 11β-hydroxylase (CYP11B1) inhibitor and autophagy activator, also inhibits the production of aldosterone, inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion in vivo. |
| PC-27980 |
BM-51
CYP4Z1 inhibitor
|
BM-51 is a potent, specific inhibitor of cytochrome P450 enzyme CYP4Z1 with IC50 of 91.7 nM, shows high selectivity against CYP4 isozymes (>100 folds). |
| PC-27657 |
Bergamottin
CYP1A1 inhibitor
|
Bergamottin (5-Geranoxypsoralen, Bergamotine) is a bioactive component of bergamot and a competitive inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki of 10.7 nM. |
| PC-25060 |
Seviteronel
CYP17A1 inhibitor
|
Seviteronel (VT-464) is a potent, selective and oral inhibitor of CYP17A1 inhibitor with 17,20-lyase IC50 of 69 nM, 10-fold selective over 17α-hydroxylase. |
| PC-25058 |
CFG920
CYP17A1 inhibitor
|
CFG920 (Lapiteronel) is a potent, selective cytochrome P450c17 (CYP17A1) inhibitor. |
| PC-24523 |
17-ODYA
CYP450 ω-hydroxylase inhibitor
|
17-ODYA (17-octadecynoic acid) is a CYP450 omega-hydroxylase (CYP450 ω-hydroxylase) inhibitor, also inhibits the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. |
| PC-24474 |
Lorundrostat
Aldosterone synthase inhibitor
|
Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase) Ki values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1, reduces systolic blood pressure. |
| PC-24397 |
SCM-08
CYP3A4 inhibitor
|
SCM-08 is a potent, selective, non-suicide CYP3A4 inhibitor with IC50 of 0.43 uM in P450-Glo inhibition assays, 47-fold selecitve over CYP3A5. |
| PC-24396 |
SCM-18
CYP3A4 inhibitor
|
SCM-18 is a potent, highly selective, non-suicide CYP3A4 inhibitor with IC50 of 0.36 uM, has >170 fold selectivity over CYP3A5 (IC50>60 uM). |
