| Cat. No. |
Product Name |
Information |
| PC-24395 |
SCM-01
CYP3A4 inhibitor
|
SCM-01 is a potent, selective, non-suicide CYP3A4 inhibitor with IC50 of 0.32 uM in P450-Glo inhibition assays, 14-fold selecitve over CYP3A5. |
| PC-24049 |
Vicadrostat
Aldosterone synthase inhibitor
|
Vicadrostat (BI 690517) is a potent, highly selective aldosterone synthase (AS) inhibitor with IC50 of 48 nM, 250-fold selectivity for aldosterone synthase compared with cortisol synthase. |
| PC-23802 |
CYP3cide
CYP3A4 inhibitor
|
CYP3cide (PF-04981517) is a potent, efficient, and specific time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) with IC50 of 0.03 uM, >500-fold selective over CYP3A5 and CYP3A7. |
| PC-23290 |
CYP2E1 inhibitor Q11
CYP2E1 inhibitor
|
CYP2E1 inhibitor Q11 is a specific Cytochrome P450 2E1 (CYP2E1) inhibitor with Ki of 897 nM. |
| PC-21449 |
Dual CYP19A1/CYP11B2 inhibitor X21
CYP19A1/CYP11B2 inhibitor
|
Dual CYP19A1/CYP11B2 inhibitor X21 is a potent and selective dual inhibitor of aromatase (CYP19A1) and aldosterone synthase (CYP11B2) with IC50 of 2.3 nM and 29 nM, respectively. |
| PC-20707 |
TP0472993
20-HETE synthesis inhibitor, CYP4F2/CYP4A11 inhibitor
|
TP0472993 is a potent, selective 20-Hydroxyeicosatetraenoic acid (20-HETE) synthesis inhibitor, inhibits 20-HETE formation in human and rat renal microsomes with IC50 of 29 and 347 nM, respectively. |
| PC-20618 |
Decursin
CYP2J2 inhibitor
|
Decursin ((+)-Decursin) is a potent anti-tumor agent and a potent protein kinase C activator, induces apoptosis and cell cycle arrest at G1 phase. |
| PC-20617 |
LKY-047
CYP2J2 inhibitor
|
LKY-047 (LKY047) is a potent, highly selective and reversible competitive cytochrome P450 CYP2J2 (CYP2J2) inhibitor with IC50 of 1.7 uM. |
| PC-49351 |
ODM-209
CYP11A1 inhibitor
|
ODM-209 (ODM209) is a potent, selective, orally bioavailable inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme) with potential antineoplastic activity, inhibits the biosynthesis of pregnenolone. |
| PC-49349 |
Opevesostat
CYP11A1 inhibitor
|
Opevesostat (ODM-208, MK-5684) is a potent, selective, orally bioavailable CYP11A1 inhibitor, inhibits the biosynthesis of pregnenolone with IC50 of 15 nM in NCI-H295R cells. |
| PC-49301 |
BMS-737
CYP17 lyase inhibitor
|
BMS-737 (BMS737) is a potent, selective, non-steroidal, reversible inhibitor of CYP17 lyase, 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. |
| PC-49296 |
BMS-351
CYP17A1 lyase inhibitor
|
BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM. |
