| Cat. No. |
Product Name |
Information |
| PC-42617 |
Cobicistat
CYP3A inhibitor
|
Cobicistat (GS-9350) is a pharmacoenhancer that acts as potent and selective inhibitor of human CYP3A with IC50 of 30-285 nM. |
| PC-45969 |
Bergaptol
CYP3A4 inhibitor
|
Bergaptol is a natural furanocoumarin that is found to be a potent inhibitor of debenzylation activity of CYP3A4 enzyme with IC50 of 24.92 uM. |
| PC-42626 |
Orteronel
CYP17A1 inhibitor
|
Orteronel (TAK-700) is a highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase. |
| PC-26843 |
CYP4Z1-IN-1
CYP4Z1 inhibitor
|
CYP4Z1-IN-1 (Compound 7c) is a potent, selective CYP4Z1 inhibitor with IC50 of 41.8 nM, >30-fold selective over CYP4F12, decreases the expression of stemness markers, spheroid formation, and metastatic ability as well as tumor-initiation capability in breast cancer cells. |
| PC-25318 |
CYP1B1 inhibitor B20
CYP1B1 inhibitor
|
CYP1B1 inhibitor B20 is a potent, highly selective CYP1B1 inhibitor with IC50 of 1.48 nM, does not inhibit CYP1A1 and CYP1A2 (IC50>80 uM). |
| PC-25295 |
CYP1A1 inhibitor 38
CYP1A1 inhibitor
|
CYP1A1 inhibitor 38 is a small molecule cytochrome P4501A1 (CYP1A1) inhibitor with IC50 of 0.02 uM and 0.001 uM in Caco-2 and CYhiRAW cells respectively, promotes macrophage phagocytosis, enhances macrophage-mediated bacterial clearance in vivo by inhibiting CYP1A1. |
| PC-25294 |
CYP1A1 inhibitor 47
CYP1A1 inhibitor
|
CYP1A1 inhibitor 47 is a small molecule cytochrome P4501A1 (CYP1A1) inhibitor with IC50 of 0.2 uM and 0.01 uM in Caco-2 and CYhiRAW cells respectively, promotes macrophage phagocytosis, enhances macrophage-mediated bacterial clearance in vivo by inhibiting CYP1A1. |
| PC-23938 |
Ketoconazole
CYP3A4 inhibitor
|
Ketoconazole (R 41400) is an imidazole anti-fungal agent and CYP3A4 and CYP24A1 inhibitor. |
| PC-23328 |
CYP4A11 and CYP4F2 inhibitor 15
CYP4A11/4F2 inhibitor
|
CYP4A11 and CYP4F2 inhibitor 15 is a potent, dual inhibitor of cytochrome P450 (CYP) 4F2 and CYP4A11 (CYP4A11/4F2) with IC50 of 120/220 nM respectively, exhibits potent suppression of 20-HETE production in both human and rat renal microsomes with IC50 of 18 nM and 37 nM. |
| PC-21418 |
TPP-IOA
Cyt c peroxidase inhibitor
|
TPP-IOA is a specific inhibitor of cytochrome c (cyt c) peroxidase activity, inhibits peroxidase activity of cardiolipin-induced cytochrome c peroxidase activity with IC50 of 5 uM. |
