| Cat. No. |
Product Name |
Information |
| PC-22560 |
MCUF-42
GC-B receptor PAM
|
MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP). |
| PC-49581 |
BI 685509
sGC activator
|
BI 685509 (Avenciguat) is a potent, selective and orally bioavailable soluble guanylate cyclase (sGC) activator, increases cGMP in human and rat platelet-rich plasma treated with ODQ with EC50 of 467 nM and 304 nM, respectively. |
| PC-38368 |
Mosliciguat
sGC activator
|
Mosliciguat (BAY 1237592) is a small molecule soluble guanylate cyclase (sGC) activator. |
| PC-73456 |
Zagociguat
sGC activator
|
Zagociguat (CY6463) is a potent, selective, brain-penetrant and orally-active soluble guanylate cyclase (sGC) activator with EC50 of 66 nM in cell-based cGMP asssays. |
| PC-72945 |
BAY-747
sGC stimulator
|
BAY-747 (BAY 1165747, BAY747) is a novel potent, selective, brain-penetrant soluble guanylate cyclase (sGC) stimulator with MEC value of 0.06 uM for stimulation of cGMP formation. |
| PC-72558 |
C-type natriuretic peptide
pGC-B activator
|
C-type natriuretic peptide (CNP, pGC-B activator) is the native particulate guanylyl cyclase B receptor (pGC-B) activator. |
| PC-72557 |
MCUF-651
Guanylyl cyclase A receptor PAM
|
MCUF-651 (MCUF651) is a small molecule guanylyl cyclase A receptor (GC-A) positive allosteric modulator (PAM), potentiate ANP-mediated cGMP with EC50 of 0.45 uM (Emax=82%) in HEK293 GC-A cells. |
| PC-36097 |
Runcaciguat
sGC activator
|
Runcaciguat (BAY1101042) is a potent, selective soluble guanylyl cyclase (sGC) stimulator/activator with EC50 of 6 nM in cGMP formation assay with sGC-overexpressing CHO cell. |
| PC-35119 |
MGV354
sGC activator
|
MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma. |
| PC-43008 |
BAY 41-2272
sGC activator
|
BAY 41-2272 is a potent, NO-independent, orally available soluble guanylate cyclase (sGC) stimulator with IC50 of 0.3 uM (relaxation of preconstricted aortic rings). |
| PC-63138 |
ODQ
sGC inhibitor
|
ODQ (sGC inhibitor ODQ) is a potent, selective, irreversible inhibitor of sGC (soluble guanylyl cyclase). |
| PC-63048 |
BAY 41-8543
sGC activator
|
BAY 41-8543 is an NO-independent sGC (soluble guanylyl cyclase) stimulator, inhibits collagen-mediated aggregation in washed human platelets (IC50=90 nM). |
