| Cat. No. |
Product Name |
Information |
| PC-63047 |
BAY 60-2770
sGC activator
|
BAY 60-2770 is an NO-independent activator of sGC (soluble guanylyl cyclase) with EC50 of 5.4 nM. |
| PC-62156 |
LY-83583
sGC inhibitor
|
LY-83583 (LY83583) is an inhibitor of soluble guanylate cyclase (sGC) and of cGMP production, inhibits sGC in human platelets with IC50 of 2 uM. |
| PC-62076 |
BPIPP
GC-C inhibitor
|
BPIPP is an inhibitor of GC-C (guanylyl cyclase type C) that inhibits stimulation of guanylyl cyclase and adenylyl cyclase, suppresses cGMP accumulation in a variety of cell lines (IC50=3.4-11.2 uM). |
| PC-61610 |
NS-2028
sGC inhibitor
|
NS-2028 (NS2028) is a potent, specific soluble guanylate cyclase (sGC) inhibitor with IC50 of 30 and 200 nM for basal and NO-stimulated enzymes, respectively. |
| PC-61609 |
S-3448
sGC activator
|
S-3448 is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.68 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC. |
| PC-61607 |
Ataciguat
sGC activator
|
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC. |
| PC-61606 |
Etriciguat
sGC activator
|
Etriciguat is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator. |
| PC-61605 |
Vericiguat
sGC stimulator
|
Vericiguat (BAY 1021189) is a novel potent, selective, orally available soluble guanylate cyclase (sGC) stimulator (MEC=0.3 uM), stimulating sGC NO-independently and in synergy with NO. |
| PC-60643 |
BI 703704
sGC activator
|
BI 703704 is a potent soluble guanylate cyclase (sGC) activator, reduces progression of renal damage in the ZSF1 rat, shows the potential as an effective therapy for diabetic nephropathy. |
| PC-60523 |
Olinciguat
sGC stimulator
|
Olinciguat (IW-1701, IW1701) is a novel potent, selective soluble guanylate cyclase (sGC) stimulator, enhances the synthesis of cGMP in response to NO binding. |
| PC-70008 |
GSK2181236A
sGC activator
|
GSK2181236A is a potent, selective soluble guanylate cyclase (sGC) stimulator that increases sGC activity (cGMP formation) with EC50s of 27 and 25 nM for rat and human sGC, respectively. |
| PC-60050 |
Praliciguat
sGC stimulator
|
Praliciguat (IW-1973, IW1973) is a potent, orally available soluble guanylate cyclase (sGC) stimulator that concentration-dependently increases the production of cGMP with EC50 of 267 nM. |
