| Cat. No. |
Product Name |
Information |
| PC-45991 |
Nelociguat
sGC stimulator
|
Nelociguat (BAY60-4552) is a direct soluble guanylate cyclase (sGC) stimulator that acts independently of nitric oxide (NO). |
| PC-22560 |
MCUF-42
GC-B receptor PAM
|
MCUF-42 is a selective, positive allosteric modulator (PAM) of guanylyl cyclase B (GC-B) receptor, dose-dependently potentiates CNP-induced cGMP with EC50 of 0.8 uM (Emax = 86%), enhances the binding affinity between GC-B and its natural ligand C-type natriuretic peptide (CNP). |
| PC-21208 |
Cinaciguat
sGC activator
|
Cinaciguat (BAY 58-2667) is a potent, small molecule activator of guanylate cyclase (sGC) with binding Kd of 3.2 nM, potently activates sGC in an NO-independent manner. |
| PC-20917 |
Riociguat
sGC stimulator
|
Riociguat (BAY 63-2521) is a potent, orally active stimulator of soluble guanylate cyclase (sGC) with MEC of 0.03 uM for achieve threefold stimulation of cGMP formation in recombinant sGC-overexpressing cell line. |
| PC-72560 |
Rat C53 peptide
pGC-B activator
|
Rat C53 peptide (C53, pGC-B activator C53) is a novel potent, selective particulate guanylyl cyclase B (pGC-B) activator, activates pGC-B/cGMP signaling pathway, and enhances cGMP generating actions. |
| PC-72559 |
Human C53 peptide
pGC-B activator
|
Human C53 peptide (C53, pGC-B activator C53) is a novel potent, selective particulate guanylyl cyclase B (pGC-B) activator, activates pGC-B/cGMP signaling pathway, and enhances cGMP generating actions. |
| PC-72558 |
C-type natriuretic peptide
pGC-B activator
|
C-type natriuretic peptide (CNP, pGC-B activator) is the native particulate guanylyl cyclase B receptor (pGC-B) activator. |
| PC-35120 |
MGV354 R-form
|
MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma.. |
| PC-61608 |
Ataciguat sodium
|
Ataciguat (HMR-1766) is a potent, specific soluble guanylate cyclase (sGC) activator with EC50 of 0.51 uM, preferentially activates the NO-insensitive heme-oxidized form of sGC. |
