| Cat. No. |
Product Name |
Information |
| PC-22225 |
Ivabradine hydrochloride
HCN Channel inhibitor
|
Ivabradine hydrochloride is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker, inhibits the cardiac pacemaker current (If). |
| PC-38762 |
NUCC-0200590
TRIP8b-HCN inhibitor
|
NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo. |
| PC-38512 |
BPU-11
HCN4 modulator
|
BPU-11 is a novel specific HCN4 channel c-linker pocket (CLP) ligand and modulator, completely abolishing the cAMP-induced shift in V1/2 (k1/2=0.42 uM). |
| PC-36083 |
HCN4 inhibitor EC18
HCN4 inhibitor
|
HCN4 inhibitor EC18 (EC18) is a HCN4-prefering blocker. |
| PC-43527 |
Zatebradine
HCN channel inhibitor
|
Zatebradine (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent. |
| PC-70127 |
ZD-7288
HCN channel inhibitor
|
ZD-7288 (ICI-D 7288) is a selective hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker. |
| PC-45567 |
Cilobradine
HCN channel inhibitor
|
Cilobradine (DKAH-269) is a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, an open channel blocker of neuronal Ih and related cardiac If channels. |
| PC-21477 |
RO-275
HCN1 inhibitor
|
RO-275 is a potent, selective HCN1 ion channel inhibitor with IC50 of 46 nM, displays 311/100/302-fold selectivity over HCN2/HCN3/HCN4. |
| PC-20860 |
Org 34167
HCN Channel inhibitor
|
Org 34167 is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation. |
| PC-43526 |
Zatebradine hydrochloride
|
Zatebradine hydrochloride (UL-FS49) is a potent blocker (antagonist) of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel, a specific bradycardic agent. |
| PC-60990 |
YM 758
|
A novel potent "funny" If current channel (If channel) inhibitor that inhibits rOct1- and hOCT1-mediated [3H]MPP uptake with IC50 of 23.8 and 40.5 uM, respectively. |
