| Cat. No. |
Product Name |
Information |
| PC-45519 |
OSU-T315
ILK inhibitor
|
OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM. |
| PC-45501 |
CWHM-12
αV integrins inhibitor
|
CWHM-12 is a potent RGD peptidomimetic inhibitor of αv integrins with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8. |
| PC-42179 |
GLPG0187
Integrin inhibitor
|
GLPG0187 (GLPG 0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1. |
| PC-47465 |
Cyclo(RGDfK)
αvβ3 integrin inhibitor
|
Cyclo(RGDfK) is a RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM. |
| PC-27620 |
BTT-3033
α2β1 integrin inhibitor
|
BTT-3033 is a specific small molecule α2β1 integrin (GPIa/IIa, VLA-2) inhibitor, inhibits CHO-α2wt cells adhesion to rat tail collagen I with EC50 of 130 nM, binds to the α2I domain. |
| PC-27179 |
C19-9N
αv/α5β1 integrin antagonist
|
C19-9N is a potent, orally bioavailable pan-αv/α5β1 integrin antagonist, exhibits high affinity for αvβ3 (Kd=0.55 μM), αvβ5 (Kd=0.61 μM), α5β1 (Kd=0.88 μM), αvβ6 (Kd=0.41 μM) and αvβ8 (Kd=0.86 μM), blocks extracellular matrix (ECM)-integrin interaction. |
| PC-24715 |
Zalunfiban dihydrochloride
αIIbβ3 integrin antagonist
|
Zalunfiban dihydrochloride (RUC-4) is a potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors. |
| PC-24102 |
RO0270608
Integrin α4β1/α4β7 inhibitor
|
RO0270608 is the active metabolite of Valategrast (R411), which is a potent, α4β1 (VLA-4) and α4β7 dual antagonist. |
