| Cat. No. |
Product Name |
Information |
| PC-38812 |
THI0019
Integrin α4β1 agonist
|
THI0019 is a small molecule agonist of the integrin α4β1 (very late antigen-4 or VLA-4) with EC50 of 1.7 uM in cell adhesion assays in which Jurkat cells bound to CS1-conjugated BSA. |
| PC-38811 |
7HP349
LFA-1 activator
|
Alintegimod (7HP349) is a small molecule activator of the integrins αLβ2 (LFA-1) and α4β1 (VLA-4). 7HP349 directly activates integrin cell adhesion receptors crucial for the generation of an immune response. |
| PC-38443 |
A-286982
LFA-1/ICAM-1 inhibitor
|
A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50 of 44 and 35 nM in LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively. |
| PC-73406 |
Bexotegrast
αvβ6/αvβ1 integrin inhibitor
|
Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. |
| PC-73352 |
C67399
TLN1-integrin β1 inhibitor
|
C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM). |
| PC-73252 |
BIRT-377
LFA-1 inhibitor
|
BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM. |
| PC-72987 |
ADH-503
CD11b agonist
|
ADH-503 (GB1275, Leukadherin-1 choline) is a small-molecule allosteric agonist of CD11b that can render tumors more sensitive to checkpoint blockade. |
| PC-72429 |
AXT107
VEGFR2-β3 inhibitor
|
AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation. |
| PC-72274 |
GSK3335103
αvβ6 inhibitor
|
GSK3335103 (GSK-3335103) is a potent, oral, small molecule RGD-mimetic αvβ6 integrin inhibitor with pKi of 9.96. |
| PC-35719 |
Valategrast hydrochloride
Integrin α4β1/α4β7 inhibitor
|
Valategrast (R-411) hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist, shows potential for Chronic obstructive pulmonary disease (COPD) and asthma. |
| PC-35718 |
Valategrast
Integrin α4β1/α4β7 inhibitor
|
Valategrast (R-411) is a potent, α4β1 (VLA-4) and α4β7 dual antagonist, shows potential for Chronic obstructive pulmonary disease (COPD) and asthma. |
| PC-35693 |
SC-68448
Integrin αvβ3 inhibitor
|
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3. |
