| Cat. No. |
Product Name |
Information |
| PC-35165 |
ALG1001
|
ALG1001 (Risuteganib, ALG-1001) is a first-in-class, RGD class oligopeptide that inhibits integrin receptors (αvβ3, αvβ5, and α5β1) associated with angiogenesis. |
| PC-35164 |
SF0166
αvβ3 integrin inhibitor
|
SF0166 (Nesvategrast, SF-0166) is a topically administered αvβ3 integrin antagonist, inhibits integrin-ligand interactions with IC50 of 0.6 nM to 13 nM for human αvβ3, αvβ6, and αvβ8. |
| PC-35072 |
ER-464195-01
Calreticulin-Integrin α inhibitor
|
ER-464195-01 is a specific, orally active inhibitor that inhibits Calreticulin (CRT) binding to integrin α subunits (ITGAs) with IC50 of 0.17, 0.36, and 0.23 uM in the interaction between CRT and ITGA α4, αL, and αM/α2/α5. |
| PC-35035 |
BI-1950
LFA-1 inhibitor
|
BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM. |
| PC-42953 |
RGDS peptide
Integrin inhibitor
|
RGDS peptide (Arg-Gly-Asp-Ser) is a integrin binding sequence that inhibits integrin receptor function, a tetrapeptide analogue of the cell attachment site of fibronectin. |
| PC-62157 |
LLP2A
α4β1 integrin inhibitor
|
LLP2A is a high-affinity, selective peptidomimetic ligand of α4β1 integrin with IC50 of 2 pM. |
| PC-62071 |
TC-I 15
α2β1 integrin inhibitor
|
TC-I 15 is a highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM. |
| PC-62001 |
MK-0429
αvβ3 integrin inhibitor
|
MK-0429 is a potent, selective, orally-active nonpeptide αvβ3 integrin inhibitor with IC50 of 0.08 nM in SPAV3 assay. |
| PC-61417 |
JK-273
α4 integrin inhibitor
|
JK-273 is a small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin. |
| PC-61300 |
BIO5192
Integrin α4β1 inhibitor
|
BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM. |
| PC-61261 |
TBC3486
α4β1 integrin inhibitor
|
TBC3486 is a potent, selective, non-peptidic integrin α4β1 (VLA-4) antagonist with IC50 of 9 nM, displays 200-fold selectivity over α4β7 (IC50=2.1 uM). |
| PC-61134 |
ML165
αIIbβ3 integrin inhibitor
|
ML165 (RUC-2) is a high-affinity, selective platelet integrin αIIbβ3 receptor antagonist with IC50 of 96 nM. |
