| Cat. No. |
Product Name |
Information |
| PC-73352 |
C67399
TLN1-integrin β1 inhibitor
|
C67399 is a small molecule that blocks the integrin β1 binding site of TLN1, reduces the malignant behaviours of TNBC in vitro (MDA-MB-231 cell, IC50=2.0 uM). |
| PC-73252 |
BIRT-377
LFA-1 inhibitor
|
BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM. |
| PC-73164 |
Cilengitide
Integrin inhibitor
|
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively. |
| PC-72987 |
ADH-503
CD11b agonist
|
ADH-503 (GB1275, Leukadherin-1 choline) is a small-molecule allosteric agonist of CD11b that can render tumors more sensitive to checkpoint blockade. |
| PC-72429 |
AXT107
VEGFR2-β3 inhibitor
|
AXT107 (Gersizangitide) is a mimetic peptide derived from collagen IV, binds integrins αvβ3 and α5β1 (Kd=1.29 and 2.21 nM), disrupts VEGFR2-β3 complex formation. |
| PC-72274 |
GSK3335103
αvβ6 inhibitor
|
GSK3335103 (GSK-3335103) is a potent, oral, small molecule RGD-mimetic αvβ6 integrin inhibitor with pKi of 9.96. |
| PC-35719 |
Valategrast hydrochloride
Integrin α4β1/α4β7 inhibitor
|
Valategrast (R411) hydrochloride is a potent, α4β1 (VLA-4) and α4β7 dual antagonist, shows potential for Chronic obstructive pulmonary disease (COPD) and asthma. |
| PC-35718 |
Valategrast
Integrin α4β1/α4β7 inhibitor
|
Valategrast (R411) is a potent, α4β1 (VLA-4) and α4β7 dual antagonist, shows potential for chronic obstructive pulmonary disease (COPD) and asthma. |
| PC-35693 |
SC-68448
Integrin αvβ3 inhibitor
|
SC-68448 (SC68448) is a potent, selective peptidomimetic antagonist of the integrin αvβ3 with IC50 of 1 nM, 100-fold selectivity over αIIbβ3. |
| PC-35657 |
Carotegrast methyl
α4 integrin inhibitor
|
Carotegrast methyl (AJM300) is a novel potent, selective, orally available alpha 4 integrin antagonist fortreatment of active ulcerative colitis. |
| PC-35546 |
BIO1211
Integrin α4β1 (VLA-4) inhibitor
|
BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1. |
| PC-35545 |
DS-70
Integrin α4β1 inhibitor
|
DS-70 (α4 integrin inhibitor DS-70) is a novel potent α/β- peptidomimetic antagonist of α4 integrin, binds to integrin α4β1 with nanomolar affinity. |
