| Cat. No. |
Product Name |
Information |
| PC-21535 |
ATN-161
Integrin inhibitor
|
ATN-161 (Ac-PHSCN-NH2) is a small peptide inhibitor of integrin alpha5 beta1 (α5β1) and alphavbeta3 (αvβ3) with binding Kd of 1.0 and 0.6 uM, respectively, inhibits breast cancer growth and metastasis. |
| PC-20146 |
E7820
Integrin α2 inhibitor
|
E7820 (E-7820) is a unique, oral sulfonamide derivative angiogenesis inhibitor, inhibits integrin α2 (ITGA2) mRNA expression and suppresses tube formation through the suppression of integrin alpha2. |
| PC-49804 |
MSR03
αVβ3 inhibitor
|
MSR03 is a potent, pure small molecule αVβ3 antagonist with IC50 of 1.5 uM for inhibition of adhesion of cells expressing human αVβ3 to immobilized fibrinogen. |
| PC-49780 |
6-B345TTQ
Paxillin inhibitor
|
6-B345TTQ is a small molecule inhibitor of the α4 integrin-paxillin interaction, impairs the interaction of native paxillin with α4 integrin, decreases α4-mediated cell migration. |
| PC-49560 |
QLT0267
ILK inhibitor
|
QLT-0267 (QLT0267) is a potent, selective inhibitor of integrin-linked kinase (ILK), inhibits the kinase activity of ILK in cell-free assay at 26 nM. |
| PC-49394 |
EMD527040
αvβ6 antagonist
|
EMD527040 (EMD 527040) is a potent, specific, nonpeptidic inhibitor of αvβ6 integrin, inhibits binding of recombinant αvβ6 to fibronectin at 6 nM as compared to >9.5 μM for αvβ3 and αvβ5 integrins. |
| PC-49346 |
TBC4746
VLA-4 inhibitor
|
TBC 4746 (AVA4746) is a small molecule mimetic of VCAM-1 that binds VLA-4 on B-ALL cells with high affinity and efficiently blocks ligand-binding with VCAM-1 with EC50 of 38.52 nM. |
| PC-49345 |
IVL745
VLA-4 inhibitor
|
IVL745 (IVL-745) is a small molecule very late antigen (VLA-4) antagonist with IC50 of 20 nM and 2 nM for adhesion to VCAM-1 and fibronectin, respectively. |
| PC-73164 |
Cilengitide
Integrin inhibitor
|
Cilengitide (EMD 121974) is a potent, selective, cyclic Arg-Gly-Asp peptide inhibitor of integrins αvβ3 and αvβ5 with IC50 4.1 and 70 nM, respectively. |
| PC-72274 |
GSK3335103
αvβ6 inhibitor
|
GSK3335103 (GSK-3335103) is a potent, oral, small molecule RGD-mimetic αvβ6 integrin inhibitor with pKi of 9.96. |
| PC-62071 |
α2β1 integrin-IN-15
|
α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM. |
| PC-45190 |
Tirofiban
|
A potent, selective inhibitor of the platelet fibrinogen receptor GPIIb/IIIa with IC50 of 9 nM, inhibition of platelet aggregation. |
