| Cat. No. |
Product Name |
Information |
| PC-45616 |
Lifitegrast
LFA-1/ICAM-1 inhibitor
|
Lifitegrast (SAR1118) is a potent LFA-1/ICAM-1 antagonist with IC50 of 9 nM in HuT78 cells. |
| PC-45511 |
Integrin-IN-27
αvβ3 integrin inhibitor
|
Integrin-IN-27 is a potent integrin αvβ3 antagonist with IC50 of 18 nM. |
| PC-45954 |
Zaurategrast
Integrin α4β1/α4β7 inhibitor
|
Zaurategrast (CDP-323, CT7758) is a potent and selective, orally bioavailable α4 integrin (α4β1/VLA-4 and, to a lesser extent, α4β7 integrin) antagonist, an ester prodrug of CT-7758. |
| PC-45519 |
OSU-T315
ILK inhibitor
|
OSU-T315 is a potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 uM. |
| PC-45501 |
CWHM-12
αV integrins inhibitor
|
CWHM-12 is a potent RGD peptidomimetic inhibitor of αv integrins with IC50s of 1.8/0.8/61/1.5/0.2 nM for αvβ1/αvβ3/αvβ5/αvβ6/αvβ8. |
| PC-42179 |
GLPG0187
Integrin inhibitor
|
GLPG0187 (GLPG 0187) is a highly potent, broad spectrum integrin receptor antagonist with IC50 of 1-10 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1. |
| PC-47465 |
Cyclo(RGDfK)
αvβ3 integrin inhibitor
|
Cyclo(RGDfK) is a RGD pipetide, potent and selective αvβ3 integrin inhibitor with Kd of 41.7 nM. |
| PC-25047 |
GS-1069518
α4β7 integrin inhibitor
|
GS-1069518 is a potent and selective α4β7 integrin inhibitor. |
| PC-25046 |
Emvistegrast
α4β7 integrin inhibitor
|
Emvistegrast (GS-1427) is an oral prodrug that is rapidly converted to the active species GS-1069518, a potent and selective α4β7 integrin inhibitor. |
| PC-24715 |
Zalunfiban dihydrochloride
αIIbβ3 integrin antagonist
|
Zalunfiban dihydrochloride (RUC-4) is a potent, selective, non-RGD-mimetic αIIbβ3 integrin receptor antagonist with IC50 of 45 nM, with no activity on αVβ3 receptors. |
| PC-24102 |
RO0270608
Integrin α4β1/α4β7 inhibitor
|
RO0270608 is the active metabolite of Valategrast (R411), which is a potent, α4β1 (VLA-4) and α4β7 dual antagonist. |
| PC-23935 |
Integrin α5β1 inhibitor MRT1
Integrin α5β1 inhibitor
|
Integrin α5β1 inhibitor MRT1 is a specific small molecule inhibitor of RGD (arginylglycylaspartic acid)-binding integrin α5β1 with IC50 of 40 nM in fluorescence polarization assays, and IC50 of 18 and 54 nM for other RGD binding β1 integrins αvβ1 and α8β1. |
