| Cat. No. |
Product Name |
Information |
| PC-21319 |
PSB-22040
MRGPRX4 agonist
|
PSB-22040 is a potent, selective agonist of MAS-related Gq protein-coupled receptor X4 (MRGPRX4) with EC50 of 19.2 nM/30.0 nM in Ca2+ assay/β-arrestin assays (variant 83S), respectively. |
| PC-49487 |
Compound 48/80
MRGPRX2 agonist
|
Compound 48/80 (C48/80) is a polymer produced by condensation of N-methyl-p-methoxyphenethylamine with formaldehyde, activates human MRGPRX2 and MRGPRX1 as well as murine MRGPRB2. |
| PC-49486 |
GE1111
MRGPRX2 inhibitor
|
GE1111 is a novel potent small molecule Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist, significantly inhibits mast cells degranulation and MRGPRX2 activation with IC50 of 5 uM. |
| PC-72741 |
MRGPRX1 inhibitor 1t
MRGPRX1 modulator
|
MRGPRX1 inhibitor 1t is a potent, selective, positive allosteric modulator (PAM) of Mas-related G protein-coupled receptor X1 (MRGPRX1) with EC50 of 0.1 uM. |
| PC-38069 |
MS47134
MRGPRX4 agonist
|
MS47134 is a potent, selective MRGPRX4 agonist with EC50 of 149 nM. |
| PC-38068 |
MRGPRX2 antagonist C9
MRGPRX2 inhibitor
|
MRGPRX2 antagonist C9 is a potent and selective MRGPRX2 inverse agonist (antagonist) with Ki of 43 nM. |
| PC-38067 |
ZINC16991592
MRGPRX2 inhibitor
|
ZINC16991592 (ZINC1592) is a selective MRGPRX2 antagonist with Ki of 189 nM. |
| PC-38066 |
MRGPRX1 agonist 1
MRGPRX1 agonist
|
MRGPRX1 agonist 1 is a highly potent MRGPRX1 agonist with EC50 of 50 nM, superior selectivity over opioid receptors. |
| PC-62228 |
ZINC-3573 racemate
MRGPRX2 agonist
|
ZINC-3573 racemate is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=3 uM), showing little activity against 315 other GPCRs and 97 representative kinases. |
| PC-62227 |
(R)-ZINC-3573
MRGPRX2 agonist
|
(R)-ZINC-3573 is a potent, selective agonist of the atypical opioid receptor MRGPRX2 (EC50=0.76 uM), showing little activity against 315 other GPCRs and 97 representative kinases. |
| PC-23468 |
MRGPRX2 antagonist Compound B
MRGPRX2 antagonist
|
MRGPRX2 antagonist Compound B is a potent, selective MRGPRX2 antagonist with IC50 of 2.9 nM for inhibition of cortistatin 14-mediated MRGPRX2 activation. |
| PC-23467 |
MRGPRX2 antagonist Compound A
MRGPRX2 antagonist
|
MRGPRX2 antagonist Compound A is a potent, selective MRGPRX2 antagonist with IC50 of 50 nM for inhibition of cortistatin 14-mediated MRGPRX2 activation. |
