| Cat. No. |
Product Name |
Information |
| PC-70189 |
Saredutant
NK2 receptor antagonist
|
Saredutant (SR48968) is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor. |
| PC-60173 |
NK1-IN-9
NK1/SERT inhibitor
|
NK1-IN-9 is a potent, orally active, dual NK1 receptor antagonist (IC50=0.5 nM) and SERT inhibitor (IC50=5.2 nM). |
| PC-42191 |
Maropitant
NK1 receptor antagonist
|
Maropitant (CJ-11972) is a selective neurokinin 1 receptor (NK1) antagonist for prevention of vomiting due to motion sickness in dogs. |
| PC-42185 |
Aprepitant
NK-1 receptor antagonist
|
Aprepitant (MK-0869) is a potent, orally active, long-acting human NK-1 receptor (substance P receptor) antagonist with IC50 of 0.09 nM. |
| PC-45396 |
NKP608
NK1 receptor antagonist
|
NKP608 (NKP-608) is a non-peptidic, specific, potent and orally active NK1 receptor antagonist with IC50 of 2.6 nM. |
| PC-44659 |
SB222200
NK3 receptor antagonist
|
SB-222200 (SB222200) is a CNS-penetrant, potent and selective NK-3 receptor antagonist with Ki of 4.4 nM (inhibition of neurokinin B binding to CHO-hNK-3R). |
| PC-27027 |
Netupitant
NK1R antagonist
|
Netupitant (CID 6451149) is a highly potent, selective and orally active neurokinin-1 receptor (NK1R) antagonist with Ki of 0.95 nM for hNK1 receptor, >1000-fold selective over NK2R and NK3R. |
| PC-27026 |
Fosnetupitant chloride monohydrochloride
NK1R antagonist
|
Fosnetupitant chloride monohydrochloride is a phosphorylated prodrug formulation of netupitant and selective neurokinin-1 receptor (NK1R) antagonist with pKi of 9.5, >1000-fold selective over NK3R. |
| PC-27025 |
Fosnetupitant
NK1R antagonist
|
Fosnetupitant is a phosphorylated prodrug formulation of netupitant and selective neurokinin-1 receptor (NK1R) antagonist with pKi of 9.5, >1000-fold selective over NK3R. |
| PC-25517 |
Fosaprepitant dimeglumine
NK1R antagonist
|
Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (PC-42185), which is a potent, selective neurokinin-1 receptor (NK1R)antagonist |
| PC-25117 |
CP-99994 dihydrochloride
NK1 antagonist
|
CP-99994 dihydrochloride is a selective, high-affinity Neurokinin-1 (substance P) receptor (NK1R) antagonist with binding Ki of 0.17 nM. |
| PC-25041 |
Dazodeunetant
NK3R antagonist
|
Dazodeunetant is a potent, selective neurokinin 3 receptor (NK3R) antagonist. |
