| Cat. No. |
Product Name |
Information |
| PC-27864 |
TACR1 inhibitor C547
TACR1 inhibitor
|
TACR1 inhibitor C547 (C547-0555) is a specific tachykinin receptor 1 (TACR1) inhibitor, selectively suppresses Substance P (SP)-induced growth and proliferation in TACR1-high pancreatic cancer cells, attenuates SP-driven ERK signaling. |
| PC-23421 |
EB1002
NK2R agonist
|
EB1002 is a potent, selective, long-acting neurokinin 2 receptor (NK2R) agonist, enhances insulin sensitization. |
| PC-23398 |
Vofopitant dihydrochloride
NK1 receptor antagonist
|
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1 receptor (NK1R) antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively. |
| PC-23397 |
Vofopitant
NK1 receptor antagonist
|
Vofopitant (GR205171) is a potent, selective and orally available tachykinin neurokinin 1 receptor (NK1R) antagonist, inhibits [3H]SP binding to the NK1 receptor with pKi values of 9.5 and 10.6 in rat and human membranes respectively. |
| PC-21757 |
Elinzanetant
NK1R/NK3R inhibitor
|
Elizanetant (NT-814, BAY3427080) is an orally active, selective neurokinin (NK) receptors NK1R and NK3R antagonist, modulates reproductive hormone secretion. |
| PC-21365 |
Talnetant
NK3R antagonist
|
Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells. |
| PC-38599 |
Tradipitant
NK1R antagonist
|
Tradipitant (VLY-686, LY686017) is a selective, orally bioavailable, centrally-acting neurokinin-1 receptor (NK1) antagonist with potential anti-emetic, anti-pruritic and anti-inflammatory activities. |
| PC-35774 |
NY0128
NMUR2 agonist
|
NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays. |
| PC-35773 |
NY0116
NMUR2 agonist
|
NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays. |
| PC-63390 |
Serlopitant
NK1R antagonist
|
Serlopitant (VPD-737, MK-0594) is a potent, selective substance P/neurokinin 1 (NK1) receptor for treating chronic pruritus. |
| PC-63134 |
Senktide
NK3R antagonist
|
Senktide is a potent, selective agonist of neuromedin K3 (NK3) receptor (EC50 =0.5-3 nM), less potently agonizes the NK1 receptor (EC50=35 µM) and is without effect on the NK2 receptor. |
| PC-63098 |
GR 64349
NK2R agonist
|
GR 64349 (GR64349) is a potent and selective tachykinin NK2 receptor (NK2R) agonist with EC50 of 3.7 nM, displays >1000- and >300-fold selectivity over NK1 and NK3 receptors, respectively. |
