| Cat. No. |
Product Name |
Information |
| PC-21365 |
Talnetant
NK3R antagonist
|
Talnetant (SB223412) is a potent, selective, competitive and brain-permeable neurokinin-3 receptor (NK3R) antagonist with Ki of 1.4 nM in hNK-3-CHO cells. |
| PC-35774 |
NY0128
NMUR2 agonist
|
NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays. |
| PC-35773 |
NY0116
NMUR2 agonist
|
NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays. |
| PC-63390 |
Serlopitant
NK1R antagonist
|
Serlopitant (VPD-737, MK-0594) is a potent, selective substance P/neurokinin 1 (NK1) receptor for treating chronic pruritus. |
| PC-63134 |
Senktide
NK3R antagonist
|
Senktide is a potent, selective agonist of neuromedin K3 (NK3) receptor (EC50 =0.5-3 nM), less potently agonizes the NK1 receptor (EC50=35 µM) and is without effect on the NK2 receptor. |
| PC-63098 |
GR-64349
NK2R agonist
|
GR-64349 is a potent and selective tachykinin NK2 receptor (NK2R) agonist with EC50 of 3.7 nM, displays >1000- and >300-fold selectivity over NK1 and NK3 receptors, respectively. |
| PC-61581 |
Casopitant mesylate
NK1R antagonist
|
Casopitant (GW679769) mesylate is a potent, selective, orally active, and brain penetrant neurokinin 1 (NK1) receptor antagonist with pKi of 9.48. |
| PC-61580 |
Casopitant
NK1R antagonist
|
Casopitant (GW679769) is a potent, selective, orally active, and brain penetrant neurokinin 1 (NK1) receptor antagonist with pKi of 9.48. |
| PC-61578 |
Vestipitant
NK1R antagonist
|
Vestipitant (GW597599) is a potent, selective, orally active NK1 receptor antagonist with pKi of 9.65. |
| PC-61237 |
MLE4901
NK3R antagonist
|
Pavinetant (MLE4901, AZD-2624) is a potent, selective, orally active neurokinin 3 (NK3R) antagonist for the treatment of menopausal hot flushes. |
| PC-60342 |
SR140333
NK1 receptor antagonist
|
Nolpitantium (SR140333) is a potent, selective, non-peptide NK1 receptor antagonist with Ki of 0.74 nM, IC50 of 1.6 nM. |
| PC-70195 |
Fezolinetant
NK3R inhibitor
|
Fezolinetant (ESN-364) is a potent, selective, orally active neurokinin-3 receptor (NK3R) antagonist with pIC50/pKi of 7.7/7.6. |
