| Cat. No. |
Product Name |
Information |
| PC-21508 |
4-PQBH
Nur77 modulator
|
4-PQBH is a small molecule Nur77-mediated cytoplasmic vacuolation and paraptosis inducer, binds to Nur77 (KD=1.17 uM) and shows potentially selective cytotoxicity to HCC cells. |
| PC-38223 |
Cl-OCH3
NR4A1 antagonist
|
Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively. |
| PC-36149 |
BI1071
Nur77 modulator
|
BI1071 (BI-1071, DIM-C-pPhCF3+MeSO3-) is a novel Nur77 modulator and modulator of the Nur77-Bcl-2 apoptotic pathway, binds Nur77 (Kd=0.17 uM) to induce its mitochondrial targeting and apoptosis. |
| PC-63275 |
C-DIM5
Nur77 modulator
|
C-DIM5 (DIM-C-pPhOCH3) is an orally active diindolylmethane (C-DIM) compound that displays anti-inflammatory and neuroprotective efficacy in vitro and in vivo, also is an agonist of the orphan nuclear receptor Nur77. |
| PC-60381 |
THPN
Nur77 agonist
|
THPN is a potent specific agonist of nuclear receptor TR3 (Nur77) with Kd of 270 nM for Nur77 LDB, induces melanoma autophagy through a mitochondrial signaling pathway. |
| PC-26968 |
DdBIC
Pyroptosis inducer, Nur77 agonist
|
DdBIC is a specific small molecule agonist of orphan nuclear receptor Nur77, binds to ligand binding domain (LBD) with ITC Kd of 714 nM, triggers GSDMC-mediated pyroptosis by regulating heme levels. |
| PC-26967 |
TMPA
Nur77 antagonist, AMPKα activator
|
TMPA is a specific, high-affinity Nur77 antagonist that binds directly to Nur77ligand-binding domain (LBD) with KD of 0.25 uM, antagonizes the Nur77-LKB1 interaction, induces LKB1 nuclear export to activate AMPKα. |
| PC-26966 |
Nur77 modulator 1
Nur77 modulator
|
Nur77 modulator 1 is a high affintiy Nur77 modulator (KD = 3.58 uM), up-regulates Nur77 expression, mediates sub-cellular localization of Nur77, induces Nur77-dependent ER stress and autophagy, and results in cell apoptosis, shows broad-spectrum antiproliferative activity against hepatoma cells with IC50 of >2.0 uM. |
| PC-26965 |
Nur77 agonist 8f
Nur77 agonist
|
Nur77 agonist 8f is an orally active small molecule Nur77 agonist., induces ferroptosis by upregulating Nur77 protein expression, increasing reactive oxygen species (ROS) and lipid peroxidation levels, and decreasing GPX4 protein expression, has binding affinity to the ligand binding domain (LBD) of Nur77 with KD of 13.8 uM, induces Nur77-mediated ferroptosis, thereby exerting anticancer activity both in vitro and in vivo. |
| PC-26964 |
NMA39
Nur77 modulator
|
NMA39 is a small-molecule Nur77 modulator (SPR Kd=563 nM) that disrupts the Nur77-Cep192 interaction, induces mitotic arrest and death in tumor cells, also blocks Nur77-PLK1 interaction during mitosis, mimicking the effect of Cdk1 inhibition. |
| PC-23124 |
Cytosporone B
Nur77 agonist
|
Cytosporone B (Csn-B, Dothiorelone G) is a specific naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with EC50 of 0.278 nM, targets the ligand binding domain of Nur77. |
| PC-21509 |
Nur77 antagonist ja
Nur77 inhibitor
|
Nur77 antagonist ja is a potent, selective antagonist of the orphan nuclear receptor Nur77 (NGFIB, TR3, SPR Kd=91 nM), exhibits antiproliferative activity against MDA-MB-231 cells with IC50 of 0.4 uM. |
