| Cat. No. |
Product Name |
Information |
| PC-38223 |
Cl-OCH3
NR4A1 antagonist
|
Cl-OCH3 is an antagonist of nuclear receptor NR4A1, decreases PD-L1 protein expression in MDA-MB-231 and 4T1 cells with EC50 of 4.4 and 4.1 uM, respectively. |
| PC-36149 |
BI1071
Nur77 modulator
|
BI1071 (BI-1071, DIM-C-pPhCF3+MeSO3-) is a novel Nur77 modulator and modulator of the Nur77-Bcl-2 apoptotic pathway, binds Nur77 (Kd=0.17 uM) to induce its mitochondrial targeting and apoptosis. |
| PC-63275 |
C-DIM5
Nur77 modulator
|
C-DIM5 (DIM-C-pPhOCH3) is an orally active diindolylmethane (C-DIM) compound that displays anti-inflammatory and neuroprotective efficacy in vitro and in vivo, also is an agonist of the orphan nuclear receptor Nur77. |
| PC-60381 |
THPN
Nur77 modulator
|
THPN is a potent nuclear receptor TR3 (Nur77)-specific targeting compound that can induce melanoma autophagy through a mitochondrial signaling pathway. |
| PC-23124 |
Cytosporone B
Nur77 agonist
|
Cytosporone B (Csn-B, Dothiorelone G) is a specific naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with EC50 of 0.278 nM, targets the ligand binding domain of Nur77. |
| PC-21509 |
Nur77 antagonist ja
Nur77 inhibitor
|
Nur77 antagonist ja is a potent, selective antagonist of the orphan nuclear receptor Nur77 (NGFIB, TR3, SPR Kd=91 nM), exhibits antiproliferative activity against MDA-MB-231 cells with IC50 of 0.4 uM. |
| PC-21508 |
4-PQBH
Nur77 modulator
|
4-PQBH is a small molecule Nur77-mediated cytoplasmic vacuolation and paraptosis inducer, binds to Nur77 (KD=1.17 uM) and shows potentially selective cytotoxicity to HCC cells. |
