| Cat. No. |
Product Name |
Information |
| PC-25071 |
Lotixparib
PARP1 inhibitor
|
Lotixparib (DM5167) is a potent, selective PARP1 inhibitor with IC50 of 0.41 nM, displays >300-fold preference for PARP1 over PARP2 in in vitro enzymatic and DNA capture assays. |
| PC-23876 |
Talazoparib
PARP1/2 inhibitor
|
Talazoparib (BMN-673) is a highly potent, selective PARP1/2 inhibitor (PARP1, IC50=0.57 nM), inhibits PARP1 and PARP2 to a similar extent with Ki of 1.20 and 0.85 nM, respectively. |
| PC-23684 |
DM5167 hydrochloride
PARP1 inhibitor
|
Lotixparib hydrochloride (DM5167 hydrochloride) is a potent, selective PARP1 inhibitor with IC50 of 0.41 nM, displays >300-fold preference for PARP1 over PARP2 in in vitro enzymatic and DNA capture assays. |
| PC-21820 |
PARP inhibitor PJ34
PARP inhibitor
|
PJ34 is a potent specific inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively. |
| PC-21186 |
XAV939
Tankyrase inhibitor
|
XAV939 is a potent small molecule inhibitor of Tankyrases with IC50 of 5 nM and 2 nM for TNKS1 and TNKS2, respectively, selectively inhibits beta-catenin-mediated transcription. |
| PC-21163 |
PARP-1 inhibitor Pip5
PARP1 inhibitor
|
PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108. |
| PC-20898 |
RBN3143
PARP14 inhibitor
|
RBN3143 (RBN-3143) is a potent, selective, NAD+-competitive catalytic inhibitor of PARP14 with IC50 of 4 nM, >300-fold selectivity over other ADP-ribosyltransferase (ART) family members. |
| PC-49753 |
PARP-1 inhibitor Pip6
PARP1 inhibitor
|
PARP-1 inhibitor Pip6 is an analog of PARP-1 type I inhibitor AZ0108, shows similar type I inhibition of PARP-1 but is 90-fold more cytotoxic than AZ0108. |
| PC-49687 |
Thioparib
pan-PARP inhibitor
|
Thioparib is a next-generation potent, orally bioavailable pan-PARP inhibitor with IC50 of 0.13/0.006 nM (PARP1/2), overcomes multiple PARPi resistance both in vitro and in vivo. |
| PC-49585 |
KMR-206
PARP7 inhibitor
|
KMR-206 (KMR206) is a potent, selective PARP7 inhibitor with IC50 of 13.7 nM, displays 75-fold selectivity for PARP7 over PARP2 and does not inhibit PARP1 up to 3 uM. |
| PC-49543 |
AZ3391
PARP1 inhibitor
|
AZ3391 is a blood-brain barrier permeable, subtype selective PARP-1 inhibitor. |
| PC-49520 |
RBN012759
PARP14 inhibitor
|
RBN012759 (RBN-012759) is a potent and highly selective PARP14 chemical probe inhibitor with biochemical IC50 of 3 nM in TR-FRET assays, >300-fold selectivity over all PARP family members. |
