| Cat. No. |
Product Name |
Information |
| PC-42678 |
A-966492
PARP inhibitor
|
A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1. |
| PC-24241 |
TDI-012804
TNKS2 inhibitor
|
TDI-012804 is a potent and selective Tankyrase 2 (TNKS2) inhibitor with IC50 of 3.46 nM in in vitro PARylation assays, has 25-fold selectivity over TNKS1, suppresses WNT signaling in TNKS depleted cells. |
| PC-24140 |
Itareparib
PARP1 inhibitor
|
Itareparib is a potent, selective PARP-1 inhibitor with potential for treatment of cancer, cardiovascular disease, central nervous system injury, and inflammation. |
| PC-23684 |
PARP1 inhibitor X
PARP1 inhibitor
|
PARP1 inhibitor X is a potent, selective poly(ADP-ribose)polymerase-1 (PARP-1) inhibitor with nano-molar activity. |
| PC-23463 |
UPF-1069
PARP-2 inhibitor
|
UPF-1069 is a potent, selective PARP-2 inhibitor with IC50 of 0.3 uM, >25-fold selective over PARP-1 (IC50= 8 uM). |
| PC-23199 |
K-756
TNKS1/2 inhibitor
|
K-756 is a small molecule inhibitor of the Wnt/β-catenin pathway with IC50 of 110 nM in Wnt/β-catenin reporter assay, and selective tankyrase (TNKS) inhibitor with IC50 of 31 and 36 nM for TNKS1 and TNKS2, stabilizes Axin1/2 by inhibiting TNKS1/2. |
| PC-23088 |
Lerzeparib
PARP inhibitor
|
Lerzeparib (TQB3823) is a novel, potent and selective PARP inhibitor with IC50 of 2.8/0.9/629.3 nM for PARP1/PARP2/Tankyrase 1, respectively. |
| PC-22676 |
HTMC0435
PARP inhibitor
|
HTMC0435 is a highly selective small molecule, orally bioavailable PARP inhibitor. |
| PC-22466 |
XLY-1
PARP7 inhibitor
|
XYL-1 is a highly potent, selective PARP7 inhibitor with IC50 of 0.6 nM, weak inhibitory effect on PARP1 (IC50 >1 uM). |
| PC-22045 |
K-476
TNKS1/2 inhibitor
|
K-476 is a highly potent and selective tankyrase (TNKS1/2) inhibitor, potently inhibits Wnt/β-catenin pathway with IC50 of 110 nM in cell-based luciferase assays. |
| PC-21163 |
PARP-1 inhibitor Pip5
PARP1 inhibitor
|
PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108. |
| PC-21009 |
kt-3283
PARP-HDAC inhibitor
|
kt-3283 is a novel bi-functional PARP-HDAC inhibitor with IC50 of 0.338 nM, 2.19 nM and 1.89 uM for PARP1, PARP2 and HDACs, respectively. |
