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Cat. No. Product Name Information
PC-60367

TNKS-IN-41

Tankyrase inhibitor

TNKS-IN-41 is a highly potent and selective tankyrase inhibitor with pIC50 of 8.5 and 8.1 for TNKS1 and TNKS2, respectively.
PC-60021

GeA-69

PARP14 inhibitor

GeA-69 (GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays.
PC-42680

Rucaparib

PARP inhibitor

Rucaparib (AG014699, PF-01367338) is a potent inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
PC-42679

Rucaparib phosphate

PARP inhibitor

Rucaparib (AG014699, PF 01367338) phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, also showing binding affinity to eight other PARP domains.
PC-42410

Olaparib

PARP inhibitor

Olaparib (AZD2281, KU-0059436) is a potent, specific, and orally active PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
PC-45620

MN-64

TNKS1 inhibitor

MN-64 is a potent and selective inhibitor of Tankyrase 1 (TNKS1) with IC50 of 6 nM.
PC-45571

NMS-P118

PARP1 inhibitor

NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2.
PC-42269

BGP-15

PARP inhibitor, Hsp72 modulator

BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels.
PC-45086

WIKI4

TNKS2 inhibitor, Wnt/β-catenin inhibitor

WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2.
PC-42683

Niraparib tosylate

PARP1/2 inhibitor

Niraparib tosylate (MK-4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
PC-42682

MK-4827 hydrochloride

PARP1/2 inhibitor

Niraparib (MK-4827) hydrochloride is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.
PC-42681

Niraparib

PARP inhibitor

Niraparib (MK-4827, MK4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2.

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