| Cat. No. |
Product Name |
Information |
| PC-42678 |
A-966492
PARP inhibitor
|
A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1. |
| PC-22676 |
HTMC0435
PARP inhibitor
|
HTMC0435 is a highly selective small molecule, orally bioavailable PARP inhibitor. |
| PC-22466 |
XLY-1
PARP7 inhibitor
|
XYL-1 is a highly potent, selective PARP7 inhibitor with IC50 of 0.6 nM, weak inhibitory effect on PARP1 (IC50 >1 uM). |
| PC-22045 |
K-476
TNKS1/2 inhibitor
|
K-476 is a highly potent and selective tankyrase (TNKS1/2) inhibitor, potently inhibits Wnt/β-catenin pathway with IC50 of 110 nM in cell-based luciferase assays. |
| PC-21820 |
PARP inhibitor PJ-34
PARP inhibitor
|
PJ34 is a potent specific inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively. |
| PC-21186 |
XAV939
Tankyrase inhibitor
|
XAV939 is a potent small molecule inhibitor of Tankyrases with IC50 of 5 nM and 2 nM for TNKS1 and TNKS2, respectively, selectively inhibits beta-catenin-mediated transcription. |
| PC-21163 |
PARP-1 inhibitor Pip5
PARP1 inhibitor
|
PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108. |
| PC-21009 |
kt-3283
PARP-HDAC inhibitor
|
kt-3283 is a novel bi-functional PARP-HDAC inhibitor with IC50 of 0.338 nM, 2.19 nM and 1.89 uM for PARP1, PARP2 and HDACs, respectively. |
| PC-49687 |
Thioparib
pan-PARP inhibitor
|
Thioparib is a next-generation potent, orally bioavailable pan-PARP inhibitor with IC50 of 0.13/0.006 nM (PARP1/2), overcomes multiple PARPi resistance both in vitro and in vivo. |
| PC-49491 |
AZ1366
TNKS1/2 inhibitor
|
AZ1366 (AZ-1366) is a potent and selective inhibitor of TNSK1/2 with IC50 of 7 nM (TNKS1), also inhibits PARP1 with IC50 of 6 nM, shows Wnt pathway inhibition in DLD-1 cells (IC50<3 nM). |
| PC-38484 |
G244-LM
Tankyrase inhibitor
|
G244-LM is a potent and specific small-molecule tankyrase inhibitor, inhibits Wnt3a-induced signaling in HEK293 human and 10T1/2 mouse cells in a reporter assay. |
| PC-38373 |
Senaparib
PARP inhibitor
|
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity. |
