| Cat. No. |
Product Name |
Information |
| PC-49490 |
NVP-TNKS656
TNKS2 inhibitor
|
NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active tankyrase inhibitor with IC50 of 6 nM (TNKS2), 5,000-fold selectivity versus PARP1 and PARP2. |
| PC-49357 |
Mortaparib Plus
mortalin-p53 inhibitor
|
Mortaparib Plus is a novel anticancer small molecule that disrupts mortalin-p53 interaction, prevents the interaction of mortalin with p53 resulting in the activation of growth arrest and apoptosis mediated by activation of p21WAF1 or BAX and PUMA signalling, respectively. |
| PC-49356 |
Mortaparib
mortalin-PARP1 inhibitor
|
Mortaparib is a dual inhibitor of mortalin-PARP1 interaction, and a p53 activating cytotoxic compound, induces activation of growth arrest and apoptosis signaling in cancer cells in vitro and in vivo. |
| PC-72899 |
AZD9574
PARP1 inhibitor
|
Palacaparib (AZD9574, AZD-9574) is a potent, selective and CNS penetrant PARP1 inhibitor, inhibits PARP1 enzymatic activity with IC50 of 0.3-2.0 nM in a panel of cell lines irrespective of the HRR status. |
| PC-49120 |
STP1002
TNKS1/2 inhibitor
|
STP1002 (Basroparib) is a potent, selective and orally active inhibitor of tankyrase 1/2 (TNKS1/2) with IC50 of 5.8/3.2 nM, respectively, shows excellent selectivity against PARP1/2 compared to XAV939. |
| PC-38617 |
OM-153
TNKS1/2 inhibitor
|
OM-153 (OM153) is a potent, selective tankyrase 1 and 2 (TNKS1/2) inhibitor with IC50 of 13 nM and 2 nM, respectively, specifically inhibits WNT/β-catenin signaling with IC50 of 0.63 nM, does not inhibit PARP1. |
| PC-38484 |
G244-LM
Tankyrase inhibitor
|
G244-LM is a potent and specific small-molecule tankyrase inhibitor, inhibits Wnt3a-induced signaling in HEK293 human and 10T1/2 mouse cells in a reporter assay. |
| PC-38373 |
Senaparib
PARP inhibitor
|
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity. |
| PC-73432 |
Nesuparib
PARP/Tankyrase inhibitor
|
Nesuparib (JPI-547, NOV140201) is a potent, oral, dual inhibitor of PARP 1/2 and Tankyrase 1/2, demonstrates anti-tumor activity in BRCA-deficient cancer. |
| PC-73117 |
JA2131
PARG inhibitor
|
JA2131 (NSC98003) is a potent, selective small molecule PARG inhibitor with IC50 of 0.4 uM. |
| PC-72966 |
COH34
PARG inhibitor
|
COH34 (PARG inhibitor COH34, NSC191252) is a potent, selective and cell-active PARG inhibitor (IC50=0.37 nM). |
| PC-72910 |
PARPYnD
PARP photoaffinity probe
|
PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482. |
