| Cat. No. |
Product Name |
Information |
| PC-35508 |
ME0328
ARTD3/PARP3 inhibitor
|
ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM. |
| PC-35506 |
ZYTP1
PARP1/2 inhibitor
|
ZYTP1 is a novel, oral PARP inhibitor that inhibits PARP1, PARP2, Tankyrase-1 and Tankyrase-2 with IC50 of 5.4, 0.7, 133.3 and 289.8 nM, respectively. |
| PC-35437 |
Amelparib
PARP1 inhibitor
|
Amelparib (JPI-289, JPI289) is a novel potent, water soluble PARP-1 inhibitor with IC50 of 18.5 nM, inhibits cellular PAR formation with IC50 of 10.7 nM. |
| PC-35379 |
OUL35 derivative 32
PARP10 inhibitor
|
OUL35 derivative 32 is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of230 nM, rescues HeLa cells from ARTD10-induced cell death. |
| PC-35378 |
OUL35
PARP10 inhibitor
|
OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family. |
| PC-63335 |
UPF1854
TNKS1 inhibitor
|
UPF1854 is a potent tankyrase inhibitor with IC50 of 12 nM and 200 nM for TNKS1 and TNKS-2 respectively, displays no cross-reactivity versus other PARP proteins. |
| PC-43304 |
AZ6102
TNKS1/2 inhibitor
|
AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6). |
| PC-43035 |
G007-LK
TNKS1/2 inhibitor
|
G007-LK is a potent, specific, metabolically stable TNKS1/2 inhibitor with IC50 of 46 nM and 25 nM, respectively. |
| PC-43025 |
E7449
PARP/TNKS inhibitor
|
E7449 (2X-121) is a potent, orally bioavailable, brain penetrable dual inhibitor of PARP1/2 and TNKS1/2 with IC50 of 2.0/1.0 nM (PARP1/2), 50-100 nM (TNKS1/2). |
| PC-42353 |
Veliparib dihydrochloride
PARP inhibitor
|
Veliparib (ABT-888) dihydrochloride is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively. |
| PC-42349 |
Veliparib
PARP inhibitor
|
Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively. |
| PC-42846 |
AG14361
PARP-1 inhibitor
|
AG14361 is a potent, specific and competitive inhibitor of PARP-1 with Ki of 5.8 nM. |
