Cat. No. |
Product Name |
Information |
PC-49753 |
PARP-1 inhibitor Pip6
PARP1 inhibitor
|
PARP-1 inhibitor Pip6 is an analog of PARP-1 type I inhibitor AZ0108, shows similar type I inhibition of PARP-1 but is 90-fold more cytotoxic than AZ0108. |
PC-49585 |
KMR-206
PARP7 inhibitor
|
KMR-206 (KMR206) is a potent, selective PARP7 inhibitor with IC50 of 13.7 nM, displays 75-fold selectivity for PARP7 over PARP2 and does not inhibit PARP1 up to 3 uM. |
PC-49520 |
RBN-012759
PARP14 inhibitor
|
RBN-012759 (RBN012759) is a potent and highly selective PARP14 chemical probe inhibitor with biochemical IC50 of 3 nM in TR-FRET assays, >300-fold selectivity over all PARP family members. |
PC-72899 |
AZD9574
PARP1 inhibitor
|
AZD9574 (AZD-9574) is a potent, selective and CNS penetrant PARP1 inhibitor, inhibits PARP1 enzymatic activity with IC50 of 0.3-2.0 nM in a panel of cell lines irrespective of the HRR status. |
PC-49120 |
STP1002
TNKS1/2 inhibitor
|
STP1002 (Basroparib) is a potent, selective and orally active inhibitor of tankyrase 1/2 (TNKS1/2) with IC50 of 5.8/3.2 nM, respectively, shows excellent selectivity against PARP1/2 compared to XAV939. |
PC-72966 |
COH34
PARG inhibitor
|
COH34 (PARG inhibitor COH34, NSC191252) is a potent, selective and cell-active PARG inhibitor (IC50=0.37 nM). |
PC-72910 |
PARPYnD
PARP photoaffinity probe
|
PARPYnD is the first cell-active photoaffinity probe (AfBP) for PARP protein class, based on triple PARP1/2/6 inhibitor AZ9482. |
PC-72698 |
AEP07
PARP4 inhibitor
|
AEP07 (AEP 07) is a selective small molecule inhibitor of PARP4 (vPARP) inhibitor with IC50 of 0.8 uM, >12-fold selective over other PARP family members. |
PC-72334 |
RBN-2397
PARP7 inhibitor
|
RBN-2397 (Atamparib, RBN2397) is a potent, selective, orally active NAD+ competitive inhibitor of PARP7 with IC50 of <3 nM and Kd of <1 nM. |
PC-72149 |
AMXI-5001
PARP inhibitor
|
AMXI-5001 (AMXI 5001) is a novel, highly potent, orally active dual PARP1/2 (IC50 5/0.05 nM) and microtubule polymerization inhibitor, inhibits intracellular PAR formation with IC50 of 7 nM. |
PC-38102 |
Venadaparib
PARP inhibitor
|
Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. |
PC-38045 |
DR2313
PARP inhibitor
|
DR2313 is a PARP inhibitor, inhibits poly(ADP-ribosyl)ation in nuclear extracts of rat brain in vitro (Ki=0.23 uM). |