| Cat. No. |
Product Name |
Information |
| PC-21621 |
Upamostat
uPA inhibitor
|
Upamostat is a serine protease inhibitor and orally bioavailable prodrug of WX-UK1, inhibit urokinase plasminogen activator (uPA) and the urokinase-type plasminogen activator (uPA) system. |
| PC-20179 |
UK122
uPA inhibitor
|
UK122 (UK-122) is potent, selective inhibitor of urokinase-type plasminogen activator (uPA) with IC50 0.2 uM in cell-free indirect uPA assays. |
| PC-49769 |
Diaplasinin
PAI-1 inhibitor
|
Diaplasinin (PAI-749) is a potent, selective antagonist of plasminogen activator inhibitor 1 (PAI-1) with IC50 of 154 nM (preservation of tPA activity) and Ki of 253 nM, blocks PAI-1 mediated inhibition of uPA with IC50 of 87 nM. |
| PC-49768 |
Tiplaxtinin
PAI-1 inhibitor
|
Tiplaxtinin (PAI-039) is a selective, orally active plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 2.7 uM and Kd of 0.48 uM. |
| PC-49102 |
IPR-3011
uPA inhibitor
|
IPR3011 is a small-molecule uPAR-uPA protein-protein interaction inhibitor with Ki of 2.4 uM. |
| PC-49101 |
WX-293
uPA inhibitor
|
WX-293 is a highly selective small-molecule inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 2.4 uM. |
| PC-49100 |
WX-340
uPA inhibitor
|
WX-340 is a highly specific and selective, peptidic cyclic competitive inhibitor of urokinase-type plasminogen activator (uPA) with Ki of 12 and 170 nM for human and mouse uPA, respectively, inhibits 10 Units of human uPA with IC50 of 90 nM. |
| PC-38547 |
AZ3976
PAI-1 inhibitor
|
AZ3976 is a small molecule inhibitor of plasminogen activator inhibitor type 1 (PAI-1) with IC50 of 26 uM in enzymatic chromogenic assay. |
| PC-35871 |
MDI-2268
PAI-1 inhibitor
|
MDI-2268 (MDI2268) is a small-molecule, in vivo-active inhibitor of plasminogen activator inhibitor type-1 (PAI-1), demonstrates excellent pharmacokinetics, potent activity against vitronectin-bound PAI-1 in vivo, and efficacy in murine model of venous thrombosis. |
| PC-35664 |
ZK824859
uPA inhibitor
|
ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM). |
| PC-35440 |
Cenupatide
uPA inhibitor
|
Cenupatide is an urokinase plasminogen activator receptor (uPAR) inhibitor for treating disorders associated altered cell migration, such as cancer.. |
| PC-35131 |
TM5007
PAI-1 inhibitor
|
TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 29 uM, exhibits no inhibitory activity against any of the closely related serpins or serine proteases at 250 uM. |
