| Cat. No. |
Product Name |
Information |
| PC-62360 |
Thr-Asp-F-amidine
PAD4 inhibitor
|
Thr-Asp-F-amidine (TDFA) is a highly potent, selective PAD4 (protein arginine deiminase 4) inhibitor with IC50 of 2.3 uM, displays ≥15-fold selectivity for PAD4 versus PAD1 and ≥50-fold versus PADs 2 and 3. |
| PC-62217 |
GSK199 hydrochloride
PAD4 inhibitor
|
GSK199 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay. |
| PC-62216 |
GSK199
PAD4 inhibitor
|
GSK199 is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 250 nM in FP binding assay (0.2 mM Ca), 200 nM in PAD4 NH3 release inhibition assay. |
| PC-62215 |
GSK484 hydrochloride
PAD4 inhibitor
|
GSK484 hydrochloride is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), 50 nM in PAD4 NH3 release inhibition assay. |
| PC-62214 |
GSK484
PAD4 inhibitor
|
GSK484 (MMV1793192) is a potent, highly selective and reversible protein arginine deiminase PAD4 inhibitor with IC50 of 80 nM in FP binding assay (0.2 mM Ca), |
| PC-61919 |
Streptonigrin
PAD4 inhibitor, RAD54 inhibitor
|
Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54. |
| PC-24594 |
PAD-PF2
PAD inhibitor
|
PAD-PF2 is a potent inhibitor of peptidylarginine deiminases (PAD1-4) with IC50 of 42.7 nM for PAD4 mediated citrullination in the fluorescent quenching assay, inhibits all four catalytically active PAD1-4 with comparable potency in a Ca2+-dependent manner. |
| PC-24593 |
PAD4 inhibitor GSK147
CAS 1549811-03-1
|
PAD4 inhibitor GSK147 is a potent, selective PAD4 inhibitor. |
| PC-23180 |
PF-3166
PAD2 inhibitor
|
PF-3166 is a potent, selective, noncovalent, cell-active peptidyl arginine deiminase 2 (PAD2) inhibitor with IC50 of 150 nM in fluorescence quenching (FQ) assay. |
| PC-23134 |
YW4-03
PAD4 inhibitor
|
YW4-03 is a small molecule peptidylarginine deiminase (PAD) inhibitor with IC50 of 5 uM against PAD4, exhibits cell-killing efficacy in osteosarcoma U2OS cells with IC50 of 2.5-5 uM. |
| PC-22866 |
Cl-amidine TFA
PAD inhibitor
|
Cl-amidine TFA is a potent, irreversible, orall active inhibitor of protein arginine deiminases (PADs) with IC50 of 0.8, 6.2, and 5.9 µM for PAD1, PAD3, and PAD4, respectively. |
