| Cat. No. |
Product Name |
Information |
| PC-20835 |
NE 52-QQ57
GPR4 antagonist
|
NE 52-QQ57 (GPR4 antagonist 13) is a potent, elective, and efficacious GPR4 antagonist with IC50 of 70 nM (hGPR4). |
| PC-49418 |
Ogremorphin-1
GPR68 inhibitor
|
Ogremorphin-1 (OGM1) is a highly specific, first-in-class small-molecule inhibitor of GPR68 with IC50 of 0.16 uM. |
| PC-49417 |
Ogremorphin
GPR68 inhibitor
|
Ogremorphin (OGM, OGM8345) is a highly specific, first-in-class small-molecule inhibitor of GPR68 with IC50 of 0.71 uM. |
| PC-49199 |
BTB09089
TDAG8/GPR65 agonist
|
BTB09089 (BTB 09089) is a specific small molecule agonist of T cell death-associated gene 8 (TDAG8, GPR65). |
| PC-72990 |
MS48107
GPR68 PAM
|
MS48107 (MS 48107) is a potent, selective, positive allosteric modulator of G protein-coupled receptor 68 (GPR68, Log(αβ/KB)=6.83). |
| PC-42974 |
ISX-9
GPR68 ligand
|
ISX-9 (Isoxazole 9) is a isoxazole stem cell-modulator small molecule and GPR68 ligand through a chemical biology-target discovery strategy to GPR68, a proton (pH) sensing G protein-coupled receptor. |
| PC-61084 |
Ogerin
GPR68 PAM
|
Ogerin (ZINC 67740571) is a selective GPR68 positive allosteric modulator (pEC50=6.83) with minimal PAM activity at the related proton-sensing GPCRs GPR4 and GPR65. |
| PC-61082 |
GPR4 antagonist 3b
GPR4 antagonist
|
GPR4 antagonist 3b is the first potent and selective proton-sensing GPCR GPR4 antagonist with IC50 of 67 nM, with no activity against TDAG8 and OGR1 (IC50>10 uM). |
| PC-23387 |
ZINC13684400
GPR65 agonist
|
ZINC13684400 is a small molecule allosteric agonist of GPR65 with EC50 of 500 nM. |
| PC-23386 |
SD2758
GPR65 inhibitor
|
SD2758 is a small molecule inhibitor of GPR65, inhibits pH-dependent cAMP induction with sub-micromolar IC50 values at pH 7.5 and between 1 and 10 µM at pH 7. |
| PC-22775 |
BRD5075
GPR65 activator
|
BRD5075 is a potent, specific activator / positive allosteric modulator (PAM) of GPR65, induces GPR65-dependent cAMP production with EC50 of 3.8 and 6.9 uM for WT GPR65 and GPR65 I231L respectively, regulates GPR65-dependent inflammatory cytokine and chemokine expression. |
| PC-20836 |
GPR4 antagonist 39c
GPR4 antagonist
|
GPR4 antagonist 39c is a potent and orally active GPR4 antagonist with IC50 of 110 nM. |
