| Cat. No. |
Product Name |
Information |
| PC-20043 |
JTE-151
RORγt antagonist
|
JTE-151 (JTE151) is a potent selective RORγ antagonist with EC50 of 14 nM, acts by suppressing overactive immune response through inhibition of RORγ related to the activation of Th17 cells. |
| PC-20041 |
BI 730357
RORγt antagonist
|
BI 730357 (Bevurogant, BI-730357) is a potent selective RORγt antagonist with IC50 of 150 nM in reporter gene assays (RGA), inhibits the secretion of IL-17A of PBMCs with IC50 of 24 nM. |
| PC-20040 |
IMU-935
RORγt inverse agonist
|
IMU-935 (Izumerogant, IMU935, IM105935) is a potent, selective and orally available inverse agonist of retinoic acid-related orphan receptor gamma (RORγt) with IC50 of 24 nM. |
| PC-49473 |
RORγt agonist 8-074
RORγt agonist
|
RORγt agonist 8-074 is a potent, selective RORγt agonist with Kd of 497 nM, shows potent RORγt agonist activity in the Gal4 reporter gene assay with EC50 of 118.7 nM, and EC50 of 19.95 nM in FRET assays. |
| PC-49023 |
BMS-336
RORγt inhibitor
|
BMS-336 is a potent, selective, orally active RORγt (RORC2) inverse agonist with EC50 of 39 nM in RORγt reporter assays. |
| PC-38747 |
PCCR-1
RORγ inhibitor
|
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR. |
| PC-38351 |
BMS-986313
RORγt inhibitor
|
BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay. |
| PC-38350 |
BMS-986251
RORγt inhibitor
|
BMS-986251 is a potent, selective, orally active RORγt inverse agonist with EC50 of 12 nM in GAL-4 reporter assay in Jurkat cell line, and 24 nM in IL-17 human whole blood assay. |
| PC-38349 |
Cedirogant
RORγt inverse agonist
|
ABBV-157 (Cedirogant) is a small molecule inhibitor (inverse agonist) of RORγT being investigated for the treatment of immune-mediated diseases (e.g. Psoriasis). |
| PC-73441 |
Retezorogant
RORγ antagonist
|
Retezorogant is a potent, selective retinoid-related orphan receptor gamma (RORγ) antagonist. |
| PC-73062 |
A-9758
RORγt inhibitor
|
A-9758 (A9758) is a selective, small molecule inverse agonist of retinoid-related orphan receptor gamma t (hRORγt IC50=38 nM). |
| PC-72400 |
JNJ-61803534
RORγt inverse agonist
|
JNJ-61803534 (JNJ 61803534) is a novel, selective and potent RORγt inverse agonist, inhibits RORγt-driven transcription with IC50 of 9.6 nM in 1-hybrid reporter assays. |
