| Cat. No. |
Product Name |
Information |
| PC-27494 |
Ruxuplam
HTT splicing modulator
|
Ruxuplam (SKY-0515) is a small molecule splicing modulator to lower mHTT and post-meiotic segregation 1 (PMS1), shows potential for treatment of Huntington disease. |
| PC-25819 |
AP232
U2AF1 inhibitor
|
AP232 (AP-232) is a specific small molecule splicing factor U2AF1-UHM inhibitor with IC50 of 7.96 uM, targets the U2 auxiliary homology motif (UHM) of U2AF1, displays 3-24-fold selectivity against other UHM proteins (RBM39-, SPF45-, PUF60-, and U2AF2-UHM). |
| PC-23055 |
Votoplam
HTT splicing modulator
|
Votoplam (PTC518) is a small molecule HTT gene modulator and splicing modifier, selectively lowers huntingtin mRNA and protein. |
| PC-22145 |
WX-02-23
FOXA1/SF3B1 ligand
|
WX-02-23 is a covalent small molecule ligand of transcription factor FOXA1 with EC50 of 2 uM in NanoBRET assay, binds FOXA1 cysteine (C258) and C1111 of spliceosomal factor SF3B1, promotes the stereoselective and site-specific binding of FOXA1 to DNA. |
| PC-20015 |
Rebecsinib
ADAR1p150 antagonist
|
Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation. |
| PC-49818 |
BPN15477
ELP1 splicing modulator
|
BPN-15477 (BPN15477) is a potent splicing modulator compound that restores correct splicing of ELP1 exon 20, increases full-length ELP1 mRNA by increasing exon 20 inclusion with EC50 of 1.9 uM in luciferase splicing assays. |
| PC-49817 |
PTC258
ELP1 splicing modulator
|
PTC-258 (PTC258) is a highly potent, specific and orally active ELP1 splicing modulator, efficiently increases full-length ELP1 mRNA and protein in FD patient fibroblasts (EC2X ELP1 protein=0.34 nM). |
| PC-73332 |
HTT-D3
HTT splicing modulator
|
HTT-D3 is a potent, CNS-penetrant, orally bioavailable huntingtin (HTT) splicing modulator, affects HTT pre-mRNA splicing and reduces HTT expression with IC50 of 8 nM. |
| PC-73327 |
CD33 splicing modulator 1
CD33 splicing modulator
|
CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein. |
| PC-73221 |
Thailanstatin B
Splicing inhibitor
|
Thailanstatin B is a potent antiproliferative natural product and pre-mRNA splicing inhibitor, potential antibody-drug conjugate payload. |
| PC-72336 |
No. 10-3
PSF inhibitor
|
No. 10-3 (PSF inhibitor No. 10-3) is a small molecule that inhibits RNA binding by PSF with IC50 of 2.2 pM (nhibiting the interaction of PSF with CTBP1-AS probe), decreases prostate cancer cell viability (22Rv1 cells IC50=1.2 uM). |
| PC-72029 |
UHMCP1
SF3b155/U2AF65 inhibitor
|
UHMCP1 is a small molecule that prevents the SF3b155/U2AF65 interaction, binds to the hydrophobic pocket of the U2AF65 UHM domain (Kd=1-20 uM), impacts splicing and cell viability. |
