| Cat. No. |
Product Name |
Information |
| PC-73332 |
HTT-D3
HTT splicing modulator
|
HTT-D3 is a potent, CNS-penetrant, orally bioavailable huntingtin (HTT) splicing modulator, affects HTT pre-mRNA splicing and reduces HTT expression with IC50 of 8 nM. |
| PC-73221 |
Thailanstatin B
Splicing inhibitor
|
Thailanstatin B is a potent antiproliferative natural product and pre-mRNA splicing inhibitor, potential antibody-drug conjugate payload. |
| PC-38057 |
Thailanstatin C
Splicing inhibitor
|
Thailanstatin C (TST-C) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent.. |
| PC-38056 |
Thailanstatin A
Splicing inhibitor
|
Thailanstatin A (TST-A) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent.. |
| PC-36117 |
VPC-80051
hnRNP A1 splicing inhibitor
|
VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1. |
| PC-62862 |
Herboxidiene
|
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. |
| PC-21151 |
HTT splicing modulator 27
HTT splicing modulator
|
HTT splicing modulator 27 is a potent, orally bioavailable, and brain-penetrant small-molecule HTT pre-mRNA splicing modulator with mHTT protein EC50 of 66 nM. |
| PC-21086 |
Pladienolide B
SF3B1 inhibitor
|
Pladienolide B is a potent inhibitor targeting the SF3B1 subunit of the spliceosome, exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. |
| PC-21062 |
SMNDC1 inhibitor 28
SMNDC1 inhibitor
|
SMNDC1 inhibitor 28 is a specific small molecule inhibitor targeting the dimethylarginine binding pocket of the SMNDC1 Tudor domain with IC50 of 0.5 uM, 30-fold selectivity for SMNDC1 over SMN. |
| PC-20015 |
Rebecsinib
ADAR1p150 antagonist
|
Rebecsinib (17S-FD-895) is a selective small-molecule inhibitor of splicing-mediated ADAR1 activation, prevents leukemia stem cell generation. |
| PC-49818 |
BPN15477
ELP1 splicing modulator
|
BPN-15477 (BPN15477) is a potent splicing modulator compound that restores correct splicing of ELP1 exon 20, increases full-length ELP1 mRNA by increasing exon 20 inclusion with EC50 of 1.9 uM in luciferase splicing assays. |
| PC-49817 |
PTC258
ELP1 splicing modulator
|
PTC-258 (PTC258) is a highly potent, specific and orally active ELP1 splicing modulator, efficiently increases full-length ELP1 mRNA and protein in FD patient fibroblasts (EC2X ELP1 protein=0.34 nM). |
