| Cat. No. |
Product Name |
Information |
| PC-49818 |
BPN15477
ELP1 splicing modulator
|
BPN-15477 (BPN15477) is a potent splicing modulator compound that restores correct splicing of ELP1 exon 20, increases full-length ELP1 mRNA by increasing exon 20 inclusion with EC50 of 1.9 uM in luciferase splicing assays. |
| PC-49817 |
PTC258
ELP1 splicing modulator
|
PTC-258 (PTC258) is a highly potent, specific and orally active ELP1 splicing modulator, efficiently increases full-length ELP1 mRNA and protein in FD patient fibroblasts (EC2X ELP1 protein=0.34 nM). |
| PC-73332 |
HTT-D3
HTT splicing modulator
|
HTT-D3 is a potent, CNS-penetrant, orally bioavailable huntingtin (HTT) splicing modulator, affects HTT pre-mRNA splicing and reduces HTT expression with IC50 of 8 nM. |
| PC-73327 |
CD33 splicing modulator 1
CD33 splicing modulator
|
CD33 splicing modulator 1 is a small-molecule CD33 pre-mRNA splicing modulator with EC50 of 7.8 uM, enhances the exclusion of CD33 exon 2, reduces full-length V-domain containing CD33 protein. |
| PC-73221 |
Thailanstatin B
Splicing inhibitor
|
Thailanstatin B is a potent antiproliferative natural product and pre-mRNA splicing inhibitor, potential antibody-drug conjugate payload. |
| PC-72029 |
UHMCP1
SF3b155/U2AF65 inhibitor
|
UHMCP1 is a small molecule that prevents the SF3b155/U2AF65 interaction, binds to the hydrophobic pocket of the U2AF65 UHM domain (Kd=1-20 uM), impacts splicing and cell viability. |
| PC-38057 |
Thailanstatin C
Splicing inhibitor
|
Thailanstatin C (TST-C) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent.. |
| PC-38056 |
Thailanstatin A
Splicing inhibitor
|
Thailanstatin A (TST-A) is a potent antiproliferative natural product, a pre-mRNA splicing inhibitor and antiproliferative agent.. |
| PC-38037 |
FR901465
Splicing modulator
|
FR901465 is an antitumor agent isolated from the fermentation broth of Pseudomonas sp. No. 2663, a splicing modulator with strong anticancer activities.. |
| PC-36117 |
VPC-80051
hnRNP A1 splicing inhibitor
|
VPC-80051 (VPC80051) is the first small molecule inhibitor of hnRNP A1 splicing activity, targets RNA-binding domain (RBD) of hnRNP A1. |
| PC-62862 |
Herboxidiene
SF3B inhibitor
|
Herboxidiene (GEX1A, TAN-1609) is a polyketide molecule first isolated from the fermentation broth of Streptomyces chromofuscus, shows in vitro antitumor activity by targeting the SF3B protein in the splicesosome. |
| PC-62507 |
Isoginkgetin
Splicing modulator
|
Isoginkgetin (Iso-ginkgetin, IsoG) is a chemical inhibitor of Pre-mRNA splicing, does not target the SF3b subunit of the U2 snRNP, inhibits splicing both in vivo and in vitro at micromolar concentrations. |
