| Cat. No. |
Product Name |
Information |
| PC-49059 |
MRX-2843
Mer inhibitor
|
MRX-2843 (UNC2371) is a potent, selective, orally available ATP-competitive type 1 inhibitor of both Mer and Flt3 with IC50 of 1.3 and 1.0 nM, respectively. |
| PC-73130 |
ONO-7475
Axl inhibitor
|
ONO-7475 (ONO7475) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations. |
| PC-72649 |
UNC5293
MER inhibitor
|
UNC5293 (UNC-5293) is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 0.9 nM, Ki 0.19 nM. |
| PC-72618 |
PF-07265807
Axl/Mer inhibitor
|
PF-07265807 (PF 07265807) is a potent, selective dual Axl/Mer inhibitor, blocks Axl- and Mer-mediated signal transduction pathways, and inhibits proliferation and migration of Axl- and Mer-overexpressing tumor cells. |
| PC-72617 |
AZ14145845
Axl/Mer inhibitor
|
AZ14145845 (Dual Axl-Mer inhibitor 32) is a potent, selective dual Axl/Mer inhibitor with pIC50 of 7.0/7.8. |
| PC-72059 |
ER-851
Axl inhibitor
|
ER-001259851-000 is a potent, selective, orally active Axl inhibitor with IC50 of 5.2 nM in cell free assays, displays >35-fold selectivity against Mer (IC50=190 nM). |
| PC-38043 |
DS-1205b
AXL kinase inhibitor
|
DS-1205b (DS1205b) is a potent, highly selective inhibitor of AXL kinase with IC50 of 1.3 nM. |
| PC-35790 |
UNC4203
Mer inhibitor
|
UNC4203 (UNC-4203) is a potent, highly selective MerTK with IC50 of 2.4 nM, displays >30- and 4 -foldfold selectivity over Alx (IC50=80 nM) and Tyro3 (IC50=9.1 nM). |
| PC-35348 |
R916562
Axl/VEGFR2 inhibitor
|
R916562 (R562) is a potent, dual Axl/VEGFR2 inhibitor with celluar IC50 of 136 nM for Axl. |
| PC-43299 |
S49076
|
S49076 is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 of <20 nM, also potently inhibits the kinase activity of mutated isoforms of MET (D1246N, Y1248D, Y1248H) and FGFR1/2. |
| PC-43298 |
SGI-7079
Axl inhibitor
|
SGI-7079 is a potent, selective Axl inhibitor with Ki of 5.7 nM, inhibits Gas6 ligand-induced tyrosine phosphorylation of human AXL expressed in HEK293T cells with EC50 of 100 nM. |
| PC-43297 |
TP-0903
Axl inhibitor
|
TP-0903 (Dubermatinib, TP0903) is a potent, selective, orally bioavailable Axl inhibitor with IC50 of 27 nM inhibits cell viability of pncreactic cancer cells (PSN1) with IC50 of 6 nM. |
