| Cat. No. |
Product Name |
Information |
| PC-26514 |
CPL423
TAM/FLT3 inhibitor
|
CPL423 is a potent selective TAM family of receptor tyrosine kinases (TYRO3, AXL, MERTK) and FLT3 inhibitor with IC50 of MERTK (0.47 nM) and FLT3 (0.94 nM), inhibits AXL and TYRO3 with IC50 of 2.15 and 6.73 nM, respectively. |
| PC-24679 |
SLC-391
Axl inhibitor
|
SLC-391 (SLC-0211) is a potent, selective small molecule inhibitor for AXL with IC50 of 9.6 nM, 4-fold selective over TYRO3 (IC=42.3 nM) and MER (IC50=44 nM). |
| PC-24678 |
AB801
Axl inhibitor
|
Ligritinib (AB801) is a highly potent, selective, and orally bioavailable AXL kinase inhibitor with biochemical IC50 of 1.8 nM, and cellular pALX IC50 of 68 nM in ELISA assays. |
| PC-20336 |
Bemcentinib
Axl inhibitor
|
Bemcentinib (R428, BGB324) is potent, selective and orally bioavailable inhibitor of Axl kinase with IC50 of 14 nM, also is an effective blocker of FAM171A2-α-syn fibril interaction both in vitro and in vivo. |
| PC-20335 |
UNC2881
Mer inhibitor
|
UNC2881 (UNC-2881) is a potent selective Mer kinase inhibitor with IC50 of 4.3 nM, 84-fold selectivity over Axl and 58-fold over Tyro3. |
| PC-20334 |
NPS-1034
MET-AXL inhibitor
|
NPS-1034 (NPS1034) is a potent, dual MET and AXL inhibitor with IC50 of 48 and 10.3 nM, respectively. |
| PC-20332 |
INCB081776
AXL/MER inhibitor
|
INCB081776 is a potent and selective dual inhibitor of AXL and MERTK with IC50 of 16 and 14 nM respectively, 30-fold selectivity over TYRO3. |
| PC-20023 |
Adrixetinib
Axl/Mer inhibitor
|
Adrixetinib is a small molecule inhibitor of Axl/Mer RTK. |
| PC-49565 |
R992
Mer inhibitor
|
R992 (MERTK inhibitor) is a novel potent, selective and orally bioavailable inhibitor of Mer tyrosine kinase (MerTK) with IC50 of 18 nM in ADP-Glo assays. |
| PC-49059 |
MRX-2843
Mer inhibitor
|
MRX-2843 (UNC2371) is a potent, selective, orally available ATP-competitive type 1 inhibitor of both Mer and Flt3 with IC50 of 1.3 and 1.0 nM, respectively. |
| PC-73130 |
ONO-7475
Axl inhibitor
|
ONO-7475 (Tamnorzatinib) is a potent inhibitor of the TAM receptor tyrosine kinase family (Axl IC50=0.7 nM), inhibits the phosphorylation of AXL and Mer, suppresses the growth of AML with FLT3 mutations. |
| PC-72649 |
UNC5293
MER inhibitor
|
UNC5293 (UNC-5293) is a potent, highly selective, orally available inhibitor of MER receptor tyrosine kinase (MERTK) with IC50 0.9 nM, Ki 0.19 nM. |
