| Cat. No. |
Product Name |
Information |
| PC-28388 |
TrkA agonist D3
TrkA agonist
|
TrkA agonist D3 is a small molecule NGF peptidomimetic ligand / agonist of TrkA receptor, induces TrkA tyrosine phosphorylation, stabilizes TrkA-TrkA homodimers, enhances ChAT production/activity, and induces neurotrophic activities in PC12 cells and primary neuronal cultures. |
| PC-28351 |
CF3CN
TrkB agonist
|
CF3CN is a brain permeable, synthetic 7,8-DHF derivative and TrkB agonist, robustly binds to the LCM/CC2 motif on TrkB extracellular domain (ECD) with Kd of 80.2 nM, activates TrkB and its downstream signaling pathway. |
| PC-28268 |
MT200605 hydrochloride
TrkB agonist
|
MT200605 is a novel small-molecule TrkB agonist, exerts BDNF-like effects by activating the TrkB receptor and its downstream signalling pathways, enhances mitochondrial ATP synthesis and exerts antioxidant and free radical scavenging effects. |
| PC-28267 |
MT200605
TrkB agonist
|
MT200605 is a novel small-molecule TrkB agonist, exerts BDNF-like effects by activating the TrkB receptor and its downstream signalling pathways, enhances mitochondrial ATP synthesis and exerts antioxidant and free radical scavenging effects. |
| PC-28111 |
pan-Trk PAM 1
pan-Trk PAM
|
pan-Trk PAM 1 (IGF-1R modulator 1) is a potent, pan-TRK positive allosteric modulator (PAM) with EC50s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB), modulates neurotrophin signalling. |
| PC-25749 |
B355252
NGF receptor agonist, UCP2 agonist
|
B355252 (B-355252) is a small molecule NGF receptor agonist, potentiates NGF-induced neurite outgrowth, also is a uncoupling protein 2 (UCP2) agonist to regulates mitochondrial dynamics and enhances mitochondrial structural integrity. |
| PC-25545 |
Np75-4A22
p75NTR inhibitor
|
Np75-4A22 is a specific small molecule inhibitor of the transmembrane domain of death receptor p75NTR (p75NTR TMD), antagonizes NGF-mediated recruitment of the actin-bundling protein fascin to p75NTR, inhibits the migration and lung invasion of human melanoma cells in mice. |
| PC-25354 |
LPM4870108
Trk inhibitor
|
LPM4870108 is a next-generation, potent pan-Trk inhibitor with IC50 of 0.2 nM, 2.4 nM, 3.5 nM and 2.3 nM for TrkC, TrkA, TrkAG595R and TrkAG667C, respectively, shows high selectivity over ALK (IC50=182 nM). |
| PC-25049 |
Eratrectinib
TRK inhibitor
|
Eratrectinib is a potent, selective Tropomyosin receptor kinase (TRK) inhibitor with antineoplastic acitivity. |
| PC-24269 |
HIFN
TrkB agonist
|
HIFN is a novel and more potent TrkB activator than HIOC, exhibits heightened TrkB activity in NIH-3T3-TrkB cells at 10 nM. |
| PC-24268 |
HIOC
TrkB agonist
|
HIOC is a selective TrkB agonist, elicits prominent TrkB activation at 500 nM, which is comparable to BDNF, potently protects retinas from light-induced retinal degeneration (LIRD). |
| PC-24089 |
TrkC.T1 antagonist CP14
TrkC.T1 inhibitor
|
Cyclic-14-KI (CP14) is a specific, noncompetitive and allosteric antagonist of TrkC truncated isoform TrkC.T1, selectively antagonize TrkC, reduces CP14 reduces the affinity of NT3 binds to TrkC.T1 with Kd of 11.5 nM. |
