| Cat. No. |
Product Name |
Information |
| PC-24269 |
HIFN
TrkB agonist
|
HIFN is a novel and more potent TrkB activator than HIOC, exhibits heightened TrkB activity in NIH-3T3-TrkB cells at 10 nM. |
| PC-24268 |
HIOC
TrkB agonist
|
HIOC is a selective TrkB agonist, elicits prominent TrkB activation at 500 nM, which is comparable to BDNF, potently protects retinas from light-induced retinal degeneration (LIRD). |
| PC-24089 |
TrkC.T1 antagonist CP14
TrkC.T1 inhibitor
|
Cyclic-14-KI (CP14) is a specific, noncompetitive and allosteric antagonist of TrkC truncated isoform TrkC.T1, selectively antagonize TrkC, reduces CP14 reduces the affinity of NT3 binds to TrkC.T1 with Kd of 11.5 nM. |
| PC-23115 |
ACD855
pan-Trk PAM
|
ACD855 (Ponazuril) is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 1.9, 3.2 and 0.8 uM for TrkA, TrkB and TrkC respectively. |
| PC-23114 |
ACD856
pan-Trk PAM
|
ACD856 is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 382 nM, 295 nM and 33 nM for TrkA, TrkB and TrkC respectively. |
| PC-22603 |
ICP-723
pan-TRK inhibitor
|
ICP-723 (Zurletrectinib) is a potent pan-TRK Inhibitor with IC50 of <1 nM for TRKA, TRKB and TRKC, potently inhibits activities of wild-type and some mutant forms of TRK. |
| PC-22476 |
TRK inhibitor 19k
TRK inhibitor
|
TRK inhibitor 19k is a potent, selective pan tropomyosin receptor kinase (pan-TRK) inhibitor with IC50 of 23/25/21 nM for TRKA/B/C, respectively. |
| PC-22385 |
LM22B-10
TrkB/TrkC agonist
|
LM22B-10 is a small moelcule agonist neurotrophin (NT) receptor TrkB and TrkC, selectively binds to and activates TrkB as well as TrkC, shows neurotrophic activitie. |
| PC-21241 |
PTX-BD10-2
TrkB/C agonist
|
PTX-BD10-2 (BD10-2) is a selective, brain-penetrant small molecule TrkB/C receptor partial agonist, shows survival-promoting activity. |
| PC-20760 |
TrkB agonist R13
TrkB agonist
|
TrkB agonist R13 is a small molecular TrkB receptor agonist prodrug, inhibits asparagine endopeptidase (AEP) and promotes bone formation. |
| PC-60902 |
LOXO-195 RS-isomer
|
The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.. |
