| Cat. No. |
Product Name |
Information |
| PC-61490 |
LM11A-31
p75 inhibitor
|
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
| PC-61489 |
LM11A-31 dihydrochloride
p75 inhibitor
|
An orally available, brain penetrant p75NTR ligand that blocks p75-mediated cell death, also increases proliferation and survival of hippocampal neural progenitors. |
| PC-70266 |
Gambogic amide
TrkA agonist
|
Gambogic amide is a potent, selective high affinity TrkA receptor agonist with Kd of 75 nM. |
| PC-70256 |
Belizatinib
ALK/TRK inhibitor
|
Belizatinib (TSR-011) is a potent, dual ALK and TrkA, TrkB and TrkC inhibitor, exhibits high affinity for wild-type recombinant ALK kinase activity with IC50 of 0.7 nM. |
| PC-70345 |
7,8-Dihydroxyflavone
TrkB agonist
|
7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone that has been found to act as a potent and selective agonist of TrkB with Kd of 320 nM. |
| PC-60903 |
LOXO-195 R racemate
Trk inhibitor
|
The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively.. |
| PC-60901 |
Selitrectinib
Trk inhibitor
|
LOXO-195 (Selitrectinib, LOXO195) is a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively. |
| PC-70173 |
Lestaurtinib
JAK2/FLT3 inhibitor
|
Lestaurtinib (KT-5555, CEP-701) is a potent, orally active JAK2, FLT3 and TrkA inhibitor with IC50 of 0.9 nM, 3 nM and < 25 nM, respectively. |
| PC-70172 |
CEP-751
Trk inhibitor
|
CEP-751 (KT-6587) is potent inhibitor of TrkA with IC50 of 2.9 nM, also inhibits TrkB, TrkC. |
| PC-70171 |
K252a
TrkB inhibitor
|
K252a (SF2370) is a potent, non-selective tyrosine protein kinase inhibitor for Trk family, CaMK and other phosphorylase kinases. |
| PC-45453 |
GW441756
TrkA inhibitor
|
GW441756 is a potent, specific TrkA inhibitor with IC50 value of 2 nM. |
| PC-22603 |
ICP-723
pan-TRK inhibitor
|
ICP-723 (Zurletrectinib) is a potent pan-TRK Inhibitor with IC50 of <1 nM for TRKA, TRKB and TRKC, potently inhibits activities of wild-type and some mutant forms of TRK. |
