| Cat. No. |
Product Name |
Information |
| PC-35679 |
CH7057288
pan-TRK inhibitor
|
CH7057288 (CH-7057288) is a novel potent and selective pan-TRK inhibitor with IC50 of 1.1/7.8/5.1 nM for TRKA/TRKB/TRKC, respectively. |
| PC-63490 |
TrkA-IN-23
TrkA inhibitor
|
TrkA-IN-23 is a highly potent, subtype selective, peripherally restricted, allosteric TrkA inhibitor with IC50 of 10 nM, 180-fold selective over TrkB and 70-fold selective over TrkC in cell based assays. |
| PC-43265 |
LOXO-101
Trk inhibitor
|
LOXO-101 (ARRY-470, Larotrectinib) is potent, selective pan-TRK inhibitor with cellular IC50 of 2-20 nM against TRKA, TRKB, and TRKC kinases. |
| PC-43144 |
Entrectinib
ROS1/TRK/ALK inhibitor
|
Entrectinib (NMS-E628, RXDX-101, NMS-01191372) is a potent, ATP-competitive, orally available pan-TRK, ROS1 and ALK inhibitor with IC50 of 1/3/5/12/7 nM for TRKA/TRKB/TRKC/ALK/ROS1, respectively. |
| PC-63210 |
AZ-23
Trk inhibitor
|
AZ-23 is a potent, selective, orally bioavailable Trk kinase inhibitor with IC50 of 2 and 8 nM for TrkA and TrkB, respectively. |
| PC-43064 |
ANA-12
TrkB inhibitor
|
ANA-12 is a selective TrkB antagonist that binds TrkB ECD-Fc with Kd of 12 uM, prevents BDNF-induced neurite outgrowth (at 10 nM), inhibits processes downstream of TrkB without altering TrkA and TrkC functions. |
| PC-63149 |
AZD1332
Trk inhibitor
|
AZD1332 is a potent, selective, ATP-competitive neurotrophic tyrosine kinase receptor (NRTK, TRK) inhibitor with IC50 of <10 nM. |
| PC-62757 |
PQC 083
NGF inhibitor
|
PQC 083 is a novel nerve growth factor (NGF) antagonist with IC50 of 7.0 uM, functionally inhibits NGF's effects on PC12 cell differentiation. |
| PC-61913 |
ALE-0540
NGF inhibitor
|
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively. |
| PC-61912 |
Ro 08-2750
NGF inhibitor
|
Ro 08-2750 (Ro 082750) is a potent, selective, non-peptide nerve growth factor (NGF) inhibitor that binds to NGF dimer with Kd of 1 uM. |
| PC-61701 |
PF-06273340
pan-TRK inhibitor
|
PF-06273340 is a potent and selective, orally bioavailable pan-Trk kinase inhibitor with IC50 of 6, 2, and 1 nM for Trk A, B and C, respectively. |
| PC-61680 |
LM22A-4
TrkB agonist
|
LM22A-4 is a small molecule BDNF mimetic that act as a direct and specific partial agonist of TrkB (EC50=200-500 pM), but not other Trks or p75(NTR). |
