| Cat. No. |
Product Name |
Information |
| PC-35792 |
BMS-823778 free base
11β-HSD1 inhibitor
|
BMS-823778 (BMS823778) freebase is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
| PC-35575 |
INCB13739
11β-HSD1 inhibitor
|
INCB13739 (INCB-13739) is a potent, selective, oral 11βHSD1 inhibitor (IC50=1.1 nM) with high seelctivity over other dehydrogenases, glucocorticoid and mineralocorticoid receptors.. |
| PC-35574 |
HSD-016
11β-HSD1 inhibitor
|
HSD-016 (HSD016) is a potent, selective, and efficacious 11β-HSD1 inhibitor with IC50 of 149 and 530 nM for mouse and human 11β-HSD1, respectively. |
| PC-35573 |
INU-101
11β-HSD1 inhibitor
|
INU-101 (INU101) is a highly potent, selective, orally acitve 11β-HSD1 inhibitor with IC50 of 26.2 nM, 37 nM and 0.6 nM for mice, rat, and human 11β-HSD1, respectively. |
| PC-35375 |
ASP3662
11β-HSD1 inhibitor
|
ASP3662 is a potent, selective, CNS-penetrable and orally active inhibitor of 11β-HSD1 with Ki of 5.3, 2.6 and 23 nM for human, mouse and rat 11β-HSD1, does not inhibit human 11β-HSD2 at 30 uM. |
| PC-63215 |
BI 187004
11β-HSD1 inhibitor
|
BI 187004 (VTP-34072) is a novel potent, selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor intended to treat type 2 diabetes mellitus (T2D).. |
| PC-62766 |
AZD 8329
11β-HSD1 inhibitor
|
AZD8329 is a potent, selective 11β-HSD1 inhibitor with IC50 of 9 nM, displays excellent selectivity versus relatedd 11β-HSD2, 17β-HSD1 and 17β-HSD3 (IC50>30 uM). |
| PC-61987 |
AZD 4017
11β-HSD1 inhibitor
|
AZD4017 (AZD-4017) is a potent, selective, and orally bioavailable human 11β-HSD1 with IC50 of 7 nM, shows no significant activity against 11β-HSD1 and 17β-HSD1, 17β-HSD3 (IC50>30 uM). |
| PC-61492 |
BMS-823778
11β-HSD1 inhibitor
|
BMS-823778 (BMS823778) is an orally available, potent and selective inhibitor of 11βHSD-1 with IC50 of 2.3 nM, displays >10,000-fold selectivity over 11βHSD-2. |
| PC-61137 |
SKI-2852
11β-HSD1 inhibitor
|
SKI-2852 is a highly potent, selective, and orally bioavailable 11β-HSD1 inhibitor with IC50 of 2.9 and 1.6 nM for hHSD1 and mHSD1, respectively. |
| PC-60448 |
BI 135585
11β-HSD1 inhibitor
|
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively. |
| PC-60371 |
UE2343
11β-HSD1 inhibitor
|
UE2343 (UE-2343, Xanamem) is a potent, orally bioavailable, brain penetrant 11β-HSD1 inhibitor with IC50 of 24 nM in cell-free assays, with no activity for isozyme 11β-HSD2. |
