Aldehyde Dehydrogenase (ALDH) (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-61349	CVT-10216 ALDH2 inhibitor	CVT-10216 (CVT10216) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).
PC-70323	Aldi-6 ALDH inhibitor	Aldi-6 is a novel small molecule ALDH inhibitor with IC50 of 600 nM, 800 nM and 1000 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively.
PC-60168	WIN-18446 ALDH1A2 inhibitor	WIN-18446 is a potent, covalent, orally active ALDH1A2 inhibitor with IC50 of 0.3 uM.
PC-45563	Alda-1 ALDH2 activator	Alda-1 is a small-molecule activator of ALDH2, particularly effective activator of ALDH22 (EC50= 20 uM, increases the activity of the mutant, ALDH22 (11-fold).
PC-45551	NCT-501 ALDH1A1 inhibitor	NCT-501 (NCT501) is a potent and highly selective inhibitor of ALDH1A1 with IC50 of 40 nM for hALDH1A1.
PC-22705	Disulfiram ALDH1 inhibitor	Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of aldehyde-dehydrogenase (ALDH1) with IC50 of 0.13 uM for ALDH1A1 and 3.4 uM for ALDH2, also inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
PC-21249	AD-9308 ALDH2 activator	AD-9308 is a water-soluble, orally bioavailable, potent, and highly selective ALDH2 activator, AD-9308 is a valine ester prodrug of a potent and selective small molecule ALDH2 activator AD-5591.

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