| Cat. No. |
Product Name |
Information |
| PC-62798 |
Pyk2-IN-25a
Pyk2 inhibitor
|
Pyk2-IN-25a is a highly potent Pyk2 (PTK2B) inhibitor with IC50 of 0.67 nM, dispalys 2-fold weakening potency for FAK (IC50=1.26 nM). |
| PC-61370 |
Conteltinib
FAK inhibitor
|
CT-707 (Conteltinib) is a novel multikinase inhibitor targeting FAK (IC50=1.6 nM), ALK and Pyk2, exerts synergistic antitumor effects against hepatocellular carcinoma in vitro and in vivo. |
| PC-70128 |
OXA-11
FAK inhibitor
|
OXA-11 is a potent and selective inhibitor of FAK phosphorylation with biochemical IC50 of 1.2 pM (pFAK Y397), cellular IC50 of 1 nM. |
| PC-60275 |
BI-853520
PTK2/FAK inhibitor
|
Ifebemtinib (BI 853520, IN10018) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays. |
| PC-45578 |
TAS-301
FAK inhibitor
|
TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits PDGF-induced tyrosine phosphorylation of both FAK and paxillin. |
| PC-42177 |
GSK-2256098
FAK inhibitor
|
GSK-2256098 (GTPL-7939) is a potent, selective, reversible and ATP-competitive inhibitor of FAK kinase with Ki of 0.4 nM. |
| PC-42601 |
PF-562271
FAK/Pyk2 inhibitor
|
PF-562271 (VS-6062) is a potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively. |
| PC-42600 |
PF-562271 besylate
FAK/Pyk2 inhibitor
|
A potent, selective, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 14 nM, respectively. |
| PC-42602 |
PF-573228
FAK inhibitor
|
PF-573228 is a potent, selective, ATP-competitive FAK inhibitor with IC50 of 4 nM. |
| PC-22945 |
M64HCl
FAK activator
|
M64HCl is a specific small molecule, water-soluble focal adhesion kinase (FAK) activator, interacts directly with the FAK kinase domain to activate FAK, induces epithelial sheet migration in vitro, and stimulates gut mucosal wound healing in vivo. |
| PC-22876 |
FAK inhibitor E2
FAK inhibitor
|
FAK inhibitor E2 is a potent selective FAK inhibitor with IC50 of 3.58 nM, inhibits FAK downstream signaling cascades (e.g., Src and AKT), induces cytotoxic autophagy and inhibits ovarian cancer metastasis and growth. |
| PC-22150 |
PF-719
Pyk2 inhibitor
|
PF-719 (PF719) is a potent, selective Pyk2 inhibitor with IC50 of 17 nM, displays 25-fold selectvity over FAK (IC50=469 nM). |
